PI3K-AKT通路专题解析（下） - 知乎专栏
丝氨酸/苏氨酸激酶 AKT（又称作蛋白激酶 B 或Protein kinase B, PKB）作为一种原癌基因，已经成为医学界主要的关注热点，这是因为它在调控各种不同细胞功能（包括代谢、生长、增殖、 …
PDK1 Gene - GeneCards | PDK1 Protein | PDK1 Antibody
2025年3月30日 · PDK1 (Pyruvate Dehydrogenase Kinase 1) is a Protein Coding gene. Diseases associated with PDK1 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and …
Phosphoinositide-dependent kinase-1 - Wikipedia
PDPK1 is a master kinase, which is crucial for the activation of AKT /PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signaling pathways …
Activation of the essential kinase PDK1 by phosphoinositide-driven
2022年4月6日 · PDK1 (3-phosphoinositide-dependent kinase 1) is a serine/threonine-protein kinase that plays a central role in regulating cell growth, survival, and proliferation. Knocking …
PDK1 pyruvate dehydrogenase kinase 1 [ (human)] - National …
Nucleus-located PDK1 regulates growth, invasion and migration of breast cancer cells. These findings highlight the potential use of PGK1 mRNA level, PGK1 promoter hypomethylation, …
Pyruvate dehydrogenase kinases (PDKs): an overview toward …
PDK1, as an important direct target for metabolism, inhibits pyruvate flux to mitochondrial respiration. A rescue of PDK1 expression in Wnt-inhibited cancer cells rescues glycolysis as …
PDK-1 (磷酸肌醇依赖性蛋白激酶-1) - MCE-生物活性分子大师
PDK-1 是 PI3K 通路中的关键节点，通过磷酸化和随后激活许多其他 AGC 激酶家族成员（如蛋白激酶 B），在胰岛素和生长因子信号传导中发挥关键作用。 PDK-1 负责调节细胞增殖和迁 …
丙酮酸脱氢酶激酶 1（PDK1）基因 | MCE - MCE-生物活性 ...
丙酮酸脱氢酶 (PDH) 是一种线粒体多酶复合物，可催化丙酮酸的氧化脱羧作用，是负责调节哺乳动物碳水化合物燃料稳态的主要酶之一。 酶活性受磷酸化/去磷酸化循环的调节。 特定丙酮酸脱 …
The Glycolytic Gatekeeper PDK1 defines different metabolic states ...
2022年3月1日 · Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable determinant of different metabolic states in acute myeloid leukemia (AML)....
Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells …
2017年11月6日 · Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH +...
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