2025年4月4日 · Sequestosome 1 (SQSTM1, p62) is a ubiquitin binding protein involved in cell signaling, oxidative stress, and autophagy (1-4). It was first identified as a protein that binds to …

Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene. [5][6][7] Also known as the ubiquitin-binding protein p62, [8] it is an autophagosome cargo protein that …

本文综述了p62蛋白的结构特征、分子功能，并系统介绍其在蛋白质稳态和信号通路调控中的多种功能，总结了p62在疾病发生发展中的复杂性与多面性，以期为p62蛋白的功能与相关疾病研 …

2020年12月17日 · p62/SQSTM1 is a multiprotein interaction hub forming cellular punctate structures known as p62 bodies. p62 is centrally involved in the degradation of ubiquitinated …

2014年7月18日 · Our results demonstrate that p62/SQSTM1 expression is upregulated in mature compared with immature myeloid cells and reveal a pro-survival function of the NF …

2021年2月26日 · We found that transglutaminase 2 (TG2) inhibition reduced high-MW SQSTM1/p62 and SQSTM1/p62 puncta under NiCl2 stimulation, indicating that TG2 regulates …

2020年4月23日 · p62/SQSTM1, encoded by gene SQSTM1, is widely known as an adaptor protein of selective autophagy to promote aggregate-prone proteins for degradation. It is also …

2016年10月20日 · However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in …

Immunofluorescence analysis of SQSTM1/p62 in Hela using p62/SQSTM1 antibody. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy …

2023年10月5日 · S -acylation of p62 enhances the affinity of p62 for microtubule-associated protein 1 light chain 3 (LC3)-positive membranes and promotes autophagic membrane …