线粒体内膜蛋白OMA1 - 知乎 - 知乎专栏
在本篇文章中，我们主要从结构、功能、调节和相关疾病4个方面详细介绍了线粒体蛋白酶OMA1。 1. OMA1结构. 2. OMA1功能. 3. OPA1-OMA1调控机制. 4. OMA1与疾病. 1. OMA1结构. Figure …
OMA1 - Wikipedia
Metalloendopeptidase OMA1, mitochondrial is an enzyme that in humans is encoded by the OMA1 gene. [5] [6] OMA1 is a Zn 2+-dependent metalloendopeptidase in the inner membrane …
OMA1 Gene - GeneCards | OMA1 Protein | OMA1 Antibody
2025年3月30日 · OMA1 (OMA1 Zinc Metallopeptidase) is a Protein Coding gene. Diseases associated with OMA1 include Snail Allergy and Optic Atrophy 11 . Among its related …
OMA1 reprograms metabolism under hypoxia to promote …
2020年12月13日 · OMA1 knockout suppresses colorectal cancer development in AOM/DSS and xenograft mice models of colorectal cancer. OMA1‐OPA1 axis is activated by hypoxia, …
OMA1—an integral membrane protease? - PMC - PubMed …
OMA1 is a mitochondrial protease. Among its substrates are DELE1, a signaling peptide, which can elicit the integrated stress response, as well as the membrane-shaping dynamin-related …
Prohibitin levels regulate OMA1 activity and turnover in neurons
2019年12月9日 · Here, we investigate the effects of modulating neuronal PHB levels on OMA1 stability and OPA1 cleavage. We demonstrate that PHB promotes OMA1 turnover, effectively …
Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure ...
2021年2月19日 · Remodeling of mitochondrial ultrastructure is a process that is critical for organelle physiology and apoptosis. Although the key players in this process—mitochondrial …
OMA1 锌金属肽酶（OMA1）基因 | MCE - MCE-生物活性分子大师
oma1 锌金属肽酶： 启用金属内肽酶活性。 参与多个过程，包括 HRI 介导的信号；蛋白水解；和线粒体组织的调节。 位于线粒体内膜。
Inhibition of mitochondrial OMA1 ameliorates osteosarcoma …
2024年11月2日 · OMA1 is an ATP-independent zinc metalloprotease essential for maintaining mitochondrial homeostasis and plays a vital role in tumorigenesis. Depending on the type...
The mitochondrial protease OMA1 acts as a metabolic safeguard …
2023年4月25日 · The peptidase OMA1 regulates mitochondrial morphology via OPA1 and stress signaling via DELE1 and orchestrates tumorigenesis and cell survival in a cell- and tissue …