The nuclear receptor 4A1 (NR4A1 for "nuclear receptor subfamily 4 group A member 1") also known as Nur77, TR3, and NGFI-B is a protein that in humans is encoded by the NR4A1 gene. [5] [6] Nuclear receptor 4A1 (NR4A1) is a member of the NR4A nuclear receptor family [7] of intracellular transcription factors.

nur77 又称为神经生长因子诱导的基因B (nerve growthfactor-induced gene B NGFI-B) 是一种细胞核孤生受体(orphan nuclear receptor) 转录因子蛋白在多种细胞的信号转导细胞周期细胞凋亡的调节中具有十分重要的作用。

孤儿核受体Nur77 作为核受体的一类,参与机体生理和病理状态下的多个过程。 Nur77可以参与细胞分化、凋亡、代谢和炎症等诸多反应,在动脉粥样硬化、骨质疏松、心肌梗死、哮喘、急性肺损伤等诸多疾病的发生发展中都起到了重要的作用。 但是对于Nur77 的研究较少,本篇文章就Nur77分子参与的凋亡以及炎症反应过程以及相关机制进行综述,有助于Nur77在疾病中的进一步研究。 Orphan nuclear receptor Nur77, as a class of nuclear receptors, is involved in several processes in the …

2021年12月17日 · Nur77 is a nuclear receptor that has been implicated as a regulator of inflammatory disease. The expression of Nur77 increases upon stimulation of immune cells and is differentially expressed in chronically inflamed organs in human and experimental models.

Nur77 expression and activation are rapidly induced by various physiological and pathologic stimuli. Once expressed, Nur77 initiates transcriptional activity and modulates expression of its target genes.

2017年1月15日 · Nur77 is an immediate early gene whose expression is rapidly upregulated by TCR signaling in murine T cells and human thymocytes. Nur77-GFP transgenes serve as specific TCR and BCR signaling reporters in murine transgenic models.

2023年4月11日 · Biochemical screening for proteins that bound LPS identified Nur77, an orphan nuclear receptor that controls the transcription of a number of genes involved in various physiological conditions. 23,24,25 Upon LPS challenge, Nur77 bound both LPS and mitochondrial DNA released from GSDMD pores on the mitochondrial membranes; Nur77 then bound NLRP3 ...

2009年3月27日 · Emerging data suggest that Nur77 influences vascular homeostasis and disease by controlling the physiology of macrophages, smooth muscle cells (SMCs), and vascular endothelium.

2021年2月1日 · Nur77 (NGFI-B) is a nuclear receptor that belongs to the Nr4a family of orphan nuclear receptors (Nr4a1). This transcription factor has been implicated in the regulation of multiple functions, such as cell cycle regulation, apoptosis, inflammation, glucose and lipid metabolism, and brain function.

These latest findings shed light on the novel roles of Nur77 as an exploitable target for new cancer therapeutics. Further work which focuses on a more complete understanding of the Nur77 interactome as well as how the different networks of Nur77 functional interactions are orchestrated in a stimulu …