2025年3月30日 · NTN1 (Netrin 1) is a Protein Coding gene. Diseases associated with NTN1 include Mirror Movements 4 and Mirror Movements 1. Among its related pathways are Netrin-1 signaling and Nervous system development. An important paralog of this gene is NTN3. Netrins control guidance of CNS commissural axons and peripheral motor axons.

Netrin-1 is a protein that in humans is encoded by the NTN1 gene. [5][6] Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development.

2024年6月28日 · Netrin-1 (NTN1) was found up-regulated in nerve stump after peripheral nerve injury (PNI). Herein, we demonstrated that NTN1-high endothelial cells (NTN1+ECs) were the critical component of vascular niche, fostering angiogenesis, axon regeneration, and repair-related phenotypes.

2024年11月27日 · Netrin-1 elicits metastatic potential of non-small cell lung carcinoma cell by enhancing cell invasion, migration and vasculogenic mimicry via EMT induction. Zhang X, et al. Cancer Gene Ther, 2018 Feb. PMID 29234153. The neuroimmune guidance cue netrin-1: a new therapeutic target in cardiovascular disease.

Netrin 属于层粘连蛋白相关分泌蛋白家族。 该基因的功能尚未确定；然而，netrin 被认为参与了发育过程中的轴突导向和细胞迁移。 netrin 的突变和表达缺失表明 netrin 的变异可能与癌症的发展有关。 [RefSeq 提供，2008 年 7 月] Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development.

2021年1月27日 · Our study suggests that niche produced netrin-1 preserves HSC quiescence and self-renewal via neogenin-1 function. Decline of netrin-1 production during ageing leads to the gradual decrease of Neo1...

2025年1月25日 · In SKCM, NTN1 was identified as an independent risk factor and demonstrated potential associations with multiple drugs. NTN1 exhibits substantial clinical utility as a prognostic marker and indicator of immune response across various tumor types. This comprehensive analysis provides insights into its potential implications in pan-cancer research.

Results demonstrate that NTN1 is an important regulator of stemness and motility of glioblastoma cells. Furthermore, it deciphers a novel mechanism where NTN1 activates Notch signaling and subsequent stemness in invasive glioblastoma cells.

2015年7月8日 · In various somatic cells, we found that reprogramming is accompanied by a transient transcriptional repression of Netrin-1 mediated by an Mbd3/Mta1/Chd4-containing NuRD complex. Mechanistically,...

Netrin-1 是一种胚胎分泌型层粘蛋白相关糖蛋白，在神经元信息传递、血管生成和细胞存活中发挥着关键作用。 Netrin-1主要在胚胎发育过程中表达，但在很大一部分人类肿瘤中，它被癌细胞和肿瘤微环境重新表达。 特别是在炎症相关的结肠直肠癌、转移性乳腺癌、肺癌、神经母细胞瘤、淋巴瘤和黑色素瘤中，这种情况已经得到证实。 在模拟这些疾病的 临床前模型 中，网织蛋白-1 及其受体之间的干扰足以引发癌细胞死亡并诱导肿瘤生长抑制。 基于这些发现，一种能中和网织蛋 …