NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene. [5][6] The NLRC4 protein is highly conserved across mammalian species. It …

In this review, we endeavor to highlight recent breakthroughs related to NLRC4 inflammasome structure and activation, important in vivo work in infection and systemic inflammation, and the …

In this review article, we provide an updated overview of NLRC4 inflammasomes, describing their composition, activation mechanisms and roles in both microbial infections and other disease …

The NLRC4 inflammasomopathies are caused by gain-of-function mutations in the gene encoding the innate immune protein NLRC4. Mutant NLRC4 promotes spontaneous formation of the …

2021年11月30日 · We explored whether NLRC4 knockdown alleviated inflammatory injury following intracerebral hemorrhage (ICH). Furthermore, we investigated whether NLRC4 …

2024年6月3日 · Epithelial human NLRC4 promotes patient survival and is associated to Type-I Interferon signaling and immune infiltration in cancer. Higher vertebrates have developed …

2024年1月4日 · Here we identify Bacillus thailandensis type III secretion system needle protein (Needle) as a potent trigger of the human NLR family apoptosis inhibitory protein …

Upon NAIP/NLRC4 activation in the intestine, epithelial cell extrusion is triggered in addition to the canonical inflammasome outcomes of cytokine cleavage and pyroptosis. Human patients with …

2025年2月19日 · Human NLRC4 expression promotes cancer survival and associates with type I interferon signaling and immune infiltration. NLRC4-mediated pyroptosis was involved in …

2025年3月30日 · NLRC4 (NLR Family CARD Domain Containing 4) is a Protein Coding gene. Diseases associated with NLRC4 include Familial Cold Autoinflammatory Syndrome 4 and …