2020年3月28日 · 在所有E3连接酶中，它们的开启开关（on-switch）中的大约三分之一是一种类似于泛素的小蛋白，即NEDD8。 NEDD8控制对其他蛋白的关闭

除cullin家族外，NEDD8还有多种底物，控制多种生物过程。 NEDD化可以抑制抗癌蛋白p53，激活癌蛋白MDM2，调控EGFR、Parkin/PINK1、HIF1α/HIF2α、Caspases/IAPs/RIP1、Histone H4等重要分子。

2025年3月30日 · NEDD8 (NEDD8 Ubiquitin Like Modifier) is a Protein Coding gene. Diseases associated with NEDD8 include Malignant Astrocytoma and Parkinson's Disease. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding.

2024年4月5日 · NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a...

NEDD8 is a protein that in humans is encoded by the NEDD8 gene. [5][6] (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL) protein becomes covalently conjugated to a limited number of cellular proteins, in a …

拟素化修饰（Neddylation） 是近年来发现的新型蛋白质翻译后修饰，可以广泛地调节生物学过程，如细胞周期、信号传导和免疫识别等。 泛素样蛋白 NEDD8 通过类似泛素化的过程与目标蛋白结合。 NEDD8和泛素的序列有59%的相同性。 目前研究最好的拟素化底物来自最大的泛素E3连接酶家族 cullin-RING连接酶 （CRLs），它们通过C端构象变化激活。 那么影响拟素化过程的工具酶、底物有哪些呢？ 拟素化有什么功能？ 国自然标书如何蹭到这个新前沿？ 今天小编就带大家一 …

2021年10月12日 · NEDD8 is best known for its function as a stimulator of cullin-RING ligases (CRLs) via neddylation of cullin family proteins 4, 5. It also modifies many other proteins, though the consequences of...

Here we show that p27 ubiquitination in HeLa cell extract requires the ubiquitin-like protein Nedd8 and enzymes that catalyze Nedd8 conjugation to proteins. Furthermore, we show that reconstitution of p27 ubiquitination activity of a recombinant SCF Skp2 depends on protein components in the Nedd8 conjugation pathway. Materials and Methods Plasmids.

Here, we review the NEDD8 pathway, its importance in cancer, and the therapeutic potential of NAE inhibition. Keywords: NEDD8, ubiquitin, cullin-RING ligase, DNA rereplication Introduction

2018年10月22日 · Spatial management of stress-induced protein aggregation is an integral part of the proteostasis network. Protein modification by the ubiquitin-like molecule NEDD8 increases upon proteotoxic...