Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene. [5][6] The protein encoded by this gene belongs to the Bcl-2 family. …

2021年9月2日 · MCL1 (myeloid cell leukemia-1) is a widely recognized pro-survival member of the Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer...

2025年3月30日 · MCL1 (MCL1 Apoptosis Regulator, BCL2 Family Member) is a Protein Coding gene. Diseases associated with MCL1 include Myeloid Leukemia and Hematologic Cancer. …

2024年3月18日 · MCL-1 is essential for promoting the survival of many normal cell lineages and confers survival and chemoresistance in cancer. Beyond apoptosis regulation, MCL-1 has …

2013年2月3日 · Our results identify a critical role for Mcl-1 in the maintenance of plasma cells. High-affinity neutralizing antibodies protect the body against foreign organisms and their toxic …

Myeloid cell leukemia-1 (MCL1), an antiapoptotic member of the BCL2 family characterized by a short half-life, functions as a rapid sensor that regulates cell death and other relevant …

2020年1月6日 · Mcl-1 is a short-lived protein, which renders it highly sensitive to changes in its synthesis or degradation. Targeting regulatory circuits that control Mcl-1 level could provide a …

2021年9月2日 · MCL1 (myeloid cell leukemia-1) is a widely recognized pro-survival member of the Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer therapy. While …

2021年9月30日 · Myeloid cell leukemia 1 (MCL-1), an anti-apoptotic oncoprotein, possess several distinct structural characteristics. Binding specificity between MCL-1 and NOXA, and …

2019年4月25日 · Myeloid cell leukemia-1 (MCL1) was the first reported gene found to be homologous to BCL2 and has since been shown by numerous studies to have an …