Monocarboxylate transporter 4 (MCT4) also known as solute carrier family 16 member 3 is a protein that in humans is encoded by the SLC16A3 gene. [5] [6]

2025年3月5日 · Our study found that MCT4 plays an important role in the occurrence and development of gastric cancer, which may mediate the occurrence of gastric cancer metastasis and shape the immunosuppressive tumor microenvironment. Gastric cancer remains a major health issue, ranking as the fourth leading cause of cancer-related deaths worldwide [1].

The monocarboxylate transporters, [1] or MCTs, are a family of proton -linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such as lactate, pyruvate, and ketones across biological membranes. [2] .

2024年3月14日 · Our findings uncovered an upregulation of key differential genes encoding MCT4, a crucial lactate transporter. In vivo and in vitro experiments delved into the significance and underlying mechanisms of MCT4-dependent lactate transport in type 2 diabetic heart injury and inflammation.

2023年2月22日 · MCT4 inhibition dramatically suppressed cell proliferation in vitro and impaired tumor growth with reduction of glucose uptake in vivo. Our results demonstrate the functional heterogeneity and redundancy of MCT1 and MCT4 in glucose metabolism and tumor progression in osteosarcoma.

2021年2月4日 · Altogether, our study shows that inhibition of MCT1 or MCT4 impairs leukemic cell proliferation, suggesting that targeting lactate metabolism may be a new therapeutic strategy for AML, and points to MCT4 as a potential therapeutic target in AML patients and to syrosingopine as a new anti-proliferative drug and inducer of autophagy to be used in ...

pathological examination of MCT1 and/or MCT4 in clinical cohorts and the outcomes should be categorised according to their expression levels into either low or high.

Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate (PubMed: 11101640, PubMed: 23935841, PubMed: 31719150). Plays a predominant role in L-lactate efflux from highly glycolytic cells (By similarity).

MCT4 exports the produced L-lactate together with a proton and prevents its accumulation and cellular acidification.

2000年8月9日 · First, MCT4 is a low-affinity MCT: for l-lactate K m values of 17±3 mM (pH-electrode) and 34±5 mM (flux measurements with l-[U-14 C]lactate) were determined. Secondly, lactate is the preferred substrate of MCT4.