Chromosome 20 was nullisomic and X was disomic. The MCF7 line retains several characteristics of differentiated mammary epithelium including ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes. The cells express the WNT7B oncogene.

MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old woman. [1] MCF-7 is the acronym of Michigan Cancer Foundation-7 , referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers. [ 2 ]

MCF-7 and MCF-10 are both cell lines used in breast cancer research, but they have distinct characteristics. MCF-7 cells are derived from metastatic breast adenocarcinoma tissue and are tumorigenic, while MCF-10 cells are derived from normal breast …

2012年4月26日 · MCF-7 is a human breast cancer cell line with estrogen, progesterone and glucocorticoid receptors [26]. It is derived from the pleural effusion of a 69-year-old Caucasian metastatic breast cancer (adenocarcinoma) in 1970 by Dr Soule of the Michigan Cancer Foundation, Detroit, MI [27].

Among many cell lines, the MCF-7 line has been widely used in in vitro breast cancer research worldwide for many years. It is positive for estrogen (ER), progesterone (PR), human epidermal growth (HER2), EGFR, and E-cadherin.

2015年3月31日 · MCF-7 as a Model of Response and Resistance to ER-Targeted Therapy. MCF-7 cells have served as a model for the study of estrogen response both in vitro and in vivo. The exact mechanism whereby estrogen stimulates MCF-7 …

2019年10月1日 · Here, we report how the ER + cell line MCF-7 can be used to dissect risk mechanisms for breast cancer. According to the traditional model of carcinogenesis, normal tissue undergoes rounds of oncogenic mutations during proliferation that eventually leads to …

We have recently developed a protocol for MCF-7 cell spheroid culture, and used this method to test the effects of different types of drugs on this estrogen-dependent breast cancer cell spheroid. Our results demonstrated that MCF-7 cells can grow spheroid in …

When grown in 3D using scaffold-free agarose hydrogels, MCF-7 human breast cancer cells self-organize to form directionally-oriented microtissues that contain a luminal space, reminiscent of the in vivo structure of the mammary gland.

MCF-7, a widely studied epithelial cancer cell line derived from breast adenocarcinoma, has characteristics of differentiated mammary epithelium. MCF7 cells can be used for detecting PI3K and MAPK involvment, along with easy detection of ERK and Akt phsophorylation.