
乳酸脱氢酶 - 百度百科
乳酸脱氢酶(lactate dehydrogenase,LD或LDH,EC1.1.1.27)是一类NAD依赖性激酶,有LDHA、LDHB、LDHC三种亚基,可构成6种四聚体同工酶。 动物乳酸脱氢酶是由4个亚单位组成的四聚体,常见的A、B两种亚基构成的5种LDH同工酶(LDH1-5),C亚基则仅组成一种LDH同工酶 …
Lactate dehydrogenase A - Wikipedia
Lactate dehydrogenase A (LDHA) is an enzyme which in humans is encoded by the LDHA gene. [5] It is a monomer of lactate dehydrogenase, which exists as a tetramer. The other main subunit is lactate dehydrogenase B (LDHB).
LDHA Gene - GeneCards | LDHA Protein | LDHA Antibody
2025年3月30日 · LDHA (Lactate Dehydrogenase A) is a Protein Coding gene. Diseases associated with LDHA include Fanconi-Bickel Syndrome and Glycogen Storage Disease Of Heart, Lethal Congenital. Among its related pathways are glycolysis (BioCyc) and Regulation of …
Lactate dehydrogenase A: A key player in carcinogenesis and …
Lactate dehydrogenase A (LDHA) facilitates glycolytic process by converting pyruvate to lactate. Numerous researches demonstrate LDHA has an aberrantly high expression in multiple cancers, which is associated with malignant progression. In this review, we summarized LDHA function in cancer research.
乳酸脱氢酶 - 维基百科,自由的百科全书
乳酸脱氢酶 (英語: Lactate dehydrogenase; EC 1.1.1.27),縮寫: LDH 或 LD,是一个广泛存在于各种生物体中的酶,包括了植物与动物。 乳酸脱氢酶存在于四种不同的酶分类中。 其中两种是依赖 细胞色素c 的酶,它们各自作用于D-乳酸 (EC 1.1.2.4) 与L-乳酸 (EC 1.1.2.3)。 乳酸脱氢酶催化 丙酮酸 与 乳酸 之间的互变并伴随着还原型烟酰胺腺嘌呤二核苷酸与其氧化型之间互变。 此酶也可催化 2-羟基丁酸 的脱氢作用,但其为较乳酸劣势的底物。 注释:也氧化其 …
Lactate dehydrogenase A regulates tumor-macrophage symbiosis …
2024年3月5日 · Combined profiling and functional studies demonstrate that lactate dehydrogenase A (LDHA)-directed extracellular signal-regulated kinase (ERK) pathway activates yes-associated...
Biochemistry, Lactate Dehydrogenase - StatPearls - NCBI Bookshelf
2023年5月1日 · Lactate dehydrogenase (LDH) is an important enzyme of the anaerobic metabolic pathway. It belongs to the class of oxidoreductases, with an enzyme commission number EC 1.1.1.27. The function of the enzyme is to catalyze the reversible conversion of lactate to pyruvate with the reduction of NAD+ to NADH and vice versa. [1] .
Lactate dehydrogenase A: A key player in carcinogenesis and ... - PubMed
Lactate dehydrogenase A (LDHA) facilitates glycolytic process by converting pyruvate to lactate. Numerous researches demonstrate LDHA has an aberrantly high expression in multiple cancers, which is associated with malignant progression. In this review, we summarized LDHA function in cancer research.
乳酸脱氢酶 A(LDHA)基因 | MCE - MCE-生物活性分子大师
该基因编码的蛋白质在无氧糖酵解的最后一步催化 L-乳酸和 NAD 转化为丙酮酸和 NADH。 该蛋白质主要存在于肌肉组织中,属于乳酸脱氢酶家族。 该基因的突变与劳力性肌红蛋白尿有关。 已发现该基因编码不同异构体的多个转录变体。 人类基因组包含该基因的几个非转录假基因。 [RefSeq 提供,2008 年 9 月] The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis.
J Transl Med:乳酸脱氢酶 A (LDHA) 介导的乳酸生成促进肺动脉高 …
2024年8月7日 · 乳酸脱氢酶a(ldha)是乳酸生成的关键酶,通过催化丙酮酸转化为乳酸,ldha在细胞代谢中起到重要的调控作用。 尽管已有研究表明乳酸在多种病理生理过程中发挥作用,但其在PH中的具体功能及机制尚不明确。