The treatment of iron overload using more than one iron chelator brings about a number of benefits, including better accessibility to various iron pools, better control on nontransferrin bound to iron, better tolerability, improved compliance, reduced myocardial iron, and improved cardiac dysfunction in iron-overload cardiomyopathy.

2024年9月24日 · Iron chelation is used to remove excess iron from the body in individuals who cannot undergo phlebotomy. There are many challenges to therapy, including when to initiate chelation, which agent to use, how to monitor efficacy and adverse effects, and how to …

Deferoxamine, Deferiprone and Deferasirox are the most important specific US FDA-approved iron chelators. Each of these chelators has their own advantages and disadvantages, various target diseases, levels of deposited iron and clinical symptoms of the afflicted patients which may affect their selection as the best modality.

Two molecules of deferasirox, an orally administered chelator, binding iron. Deferasirox is used in the treatment of transfusional iron overload in people with thalassemia. Chelation therapy is a medical procedure that involves the administration of chelating agents to remove heavy metals from the body. [1] .

The iron chelator, desferrioxamine, is used to remove excess iron that accumulates with chronic blood transfusions. Many chelators are used in chemistry and industry. Only a few are clinically useful since most have dangerous side-effects.

Iron-dependent microorganisms have evolved a strategy to solve the problems of bioavailability and toxicity of iron through the synthesis of siderophores (low-molecular mass Fe 3+-specific chelators) employed for iron uptake and storage .

The primary role of iron-chelation therapy is to prevent premature death from heart attack due to myocardial iron overload. Statistically 50% of patients with thalassemia major die of heart attack before the age of 35, primarily due to iron-related heart failure.

The primary goal of chelation therapy is to maintain safe levels of body iron at all times, by balancing iron intake from blood transfusion with iron excretion by chelation (iron balance).

2016年10月1日 · Deferoxamine, Deferiprone and Deferasirox are the most important specific US FDA-approved iron chelators. Each of these chelators has their own advantages and disadvantages, various target diseases, levels of deposited iron and clinical symptoms of the afflicted patients which may affect their selection as the best modality.

There are two goals of iron chelation therapy: the binding of toxic non-transferrin bound iron in the plasma and the removal of iron from the body. Detoxification of excess iron is probably the most important function of chelation therapy.