Mathematical Models for Immunology: Current State of the Art …
The innate immune system focuses on the physical and chemical barriers formed of cells and molecules that recognise foreign pathogens. The adaptive immune system focuses on the lymphocytes’ action to clear these pathogens.
On the computational modeling of the innate immune system
2013年4月17日 · The model proposed by Su et al uses a system of PDEs to represent the spatial dynamics of the innate and adaptive immune systems. It considers the simplest form of antigens, the molecular constituents of pathogen patterns, taking into account all the basic factors of an immune response: antigens, cells of the immune system, cytokines and ...
Modelling the innate immune system in microphysiological …
Recent studies suggest that infection can be detected by innate immune cells through pattern-recognition receptors (PRRs). There are three categories of PRRs: secreted, membrane bound, and phagocytic which are found in the blood stream, on cell membranes, and in the cytosol.
The Basic Immune Simulator: An agent-based model to study the ...
2007年9月27日 · We introduce the Basic Immune Simulator (BIS), an agent-based model created to study the interactions between the cells of the innate and adaptive immune system. Innate immunity, the initial host response to a pathogen, generally precedes adaptive immunity, which generates immune memory for an antigen.
Zebrafish: model for the study of inflammation and the innate immune ...
Adult zebrafish which have complete (innate and adaptative) immune systems offer also advantages over other vertebrate infection models: small size, relatively rapid life cycle, ease of breeding, and a growing list of molecular tools for the study of infectious diseases.
Implementation of a Computational Model of the Innate Immune System
In this scenario, the objective of this work is to model the dynamics of some cells and molecules of the HIS during an immune response to lipopolysaccharide (LPS) in a section of the tissue. The LPS constitutes the cellular wall of Gram-negative bacteria, and it is a highly immunogenic molecule, which means that it has a remarkable capacity to ...
Agent‐Based Modeling of the Immune System: NetLogo, a …
2014年4月22日 · Toll-like receptors (TLRs) represent a class of proteins playing an important function in the innate immune system. They are receptors usually expressed in macrophages and dendritic cells that recognize structurally conserved molecules derived from microbes. They are fundamental in activating the innate immune system response.
The conceptual foundations of innate immunity: Taking stock 30 …
2024年4月9日 · Innate immunity provides the first barrier to infection in vertebrates, and it is the sole mechanism of host defense in invertebrates and plants. Innate immunity also plays a critical role in maintaining homeostasis, shaping the microbiota, and in disease contexts such as cancer, neurodegeneration, metabolic syndromes, and aging.
Reproducibility of Two Innate Immune System Models
2016年11月24日 · We reproduce two representative models of the innate immune system. The first model by Rocha et al. describes the dynamics of the innate immune response by ordinary differential equations, focusing on LPS, neutrophils, resting macrophages, and …
Trained immunity, tolerance, priming and differentiation: distinct ...
2020年12月8日 · Trained immunity has been defined as one form of adaptation of innate host defense mechanisms or a de facto innate immune memory. Following exposure to particular...