Injectable hydrogel with doxorubicin-loaded ZIF-8 nanoparticles …
2024年5月1日 · Herein, an injectable hydrogel system encapsulated with anti-tumor, anti-oxidant dual functional nanoparticles has been developed in order to prevent tumor relapse after surgery and promote...
Injectable Hydrogels Encapsulating Dual-Functional Au@Pt …
2023年1月25日 · A new heart therapy comprised of cardiac implants encapsulated within an injectable extracellular matrix-gold nanoparticle composite hydrogel is reported. The particles on the collagenous fibers within the hydrogel promote fast transfer of elec. signal between cardiac cells, leading to the functional assembly of the cardiac implants.
Injectable hydrogel with selenium nanoparticles delivery for …
2023年12月1日 · A novel injectable hydrogel to deliver selenium nanoparticles (SeNPs) was proposed to intervene selenoprotein expression for osteoarthritis treatment. The hydrogels based on oxidized hyaluronic acid (OHA) cross-linked with hyaluronic acid-adipic acid dihydrazide (HA-ADH) was formulated to load SeNPs through a Schiff base reaction.
Multifunctional Injectable Hydrogel for In Vivo Diagnostic and ...
2022年1月11日 · Injectable hydrogels show high potential for in vivo biomedical applications owing to their distinctive mode of administration into the human body. In this study, we propose a material design strategy for developing a multifunctional injectable hydrogel with good adhesiveness, stretchability, and bioresorbability.
Collagen fibril-like injectable hydrogels from self-assembled ...
2024年2月1日 · In summary, by crosslinking self-assembled HML nanoparticles, we have developed a collagen fibril-like injectable hydrogel with low stiffness, high compressive strength, anti-swelling properties, sustained drug release ability, and biodegradability.
An injectable hydrogel containing versatile nanoparticles with ...
An injectable alginate hydrogel is engineered to locally deliver versatile nanoparticles exhibiting antioxidant and antifibrotic properties to the infarcted region of the heart. Intramyocardial injection of this composite hydrogel inhibits cell apoptosis, enhances angiogenesis, and prevents myocardial fibrosis, thereby improving cardiac ...
Self-Healing Injectable Hydrogels for Tissue Regeneration
2022年8月5日 · Injected hydrogels can facilitate tissue regeneration in multiple ways owing to their viscoelastic and diffusive nature, ranging from simple mechanical support, spatiotemporally controlled delivery of cells or therapeutics, to local recruitment and modulation of host cells to promote tissue regeneration.
Sustained release of drug-loaded nanoparticles from injectable ...
Herein, we develop an injectable hydrogel system composed of a macrophage-targeted nanoparticle (cyclodextrin nanoparticles, CDNPs) crosslinked by adamantane-modified hyaluronic acid (Ad-HA). The polymer-nanoparticle hydrogel uniquely leverages cyclodextrin's interaction with small molecule drugs to create a spatially discrete drug reservoir ...
Hydrogels for RNA delivery - Nature Materials
2023年3月20日 · Injectable hydrogels with self-healing properties are extremely useful for heart delivery, while topical hydrogels with adhesive properties are preferred for RNA delivery to the skin.
Injectable Hydrogels for Programmable Nanoparticle Release
2024年11月13日 · Injectable hydrogels represent a promising strategy for the extended release of biological molecules, thereby reducing the frequency of injections. This study introduces a novel system based on Michael addition of dextran and polyethylene glycol (PEG) polymers functionalized with oxanorbornadiene (OND) and thiol groups, respectively.