Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. [2] . They are produced by a group of T helper cell known as T helper 17 cell in response to their stimulation with IL-23. Originally, Th17 was identified in 1993 by Rouvier et al. who isolated IL17A transcript from a rodent T-cell hybridoma. [3] .

Interleukin-17 (IL-17, also known as IL-17A) is a key cytokine that links T cell activation to neutrophil mobilization and activation. As such, IL-17 can mediate protective innate immunity to pathogens or contribute to the pathogenesis of ...

2023年10月11日 · Interleukin 17 (IL-17) is an important cytokine that has several roles in host defense responses against mucosal infections; additionally, it is a primary pathologic cytokine and therapeutic...

2 天之前 · IL-17 acts on the amygdala to increase anxiety and on the somatosensory cortex to enhance sociability. This suggests a close connection between the immune and nervous systems. IL-17's dual role as ...

IL-17 has come a long way in 25 years: from an obscure cytokine belonging to a poorly-understood cytokine subfamily to a signature of a key T helper cell population and a key therapeutic target in human autoimmune disease.

2019年4月16日 · Here, we discuss the functions of the IL-17 family, with a focus on the balance between the pathogenic and protective roles of IL-17 in cancer and autoimmune disease, including results of therapeutic blockade and novel aspects of IL-17 signal transduction regulation.

Interleukin-17 (IL-17) and IL-17-producing cells have been shown to play important roles in inflammation and the immune response. IL-17 is believed to be mainly produced by T helper 17 (Th17) cells, a unique helper T-cell subset different from Th1 and Th2 cells.

2019年11月19日 · IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes, including host defense, tissue repair, the pathogenesis of inflammatory disease and the...

3 天之前 · IL-17 ligands require binding to IL-17R complex comprising of two distinct subunits for initiating downstream signaling events. 25, 26, 27 We previously found that neurons in the S1DZ express IL-17RA, and this expression is involved in promoting social interaction. 21 To identify additional IL-17R subunits that may play a critical role in the ...

2017年5月18日 · Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this cytokine is a central player in immunity at the sites most exposed to microorganisms. Although it has...