IFNG, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoan infections. IFNG is an important activator of macrophages and inducer of major histocompatibility complex class II molecule expression.

2025年3月30日 · IFNG (Interferon Gamma) is a Protein Coding gene. Diseases associated with IFNG include Immunodeficiency 69 and Hepatitis C Virus. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Gene expression (Transcription).

2018年6月19日 · IFNγ is a cytokine that is primarily produced by cells of the immune system, including innate-like lymphocyte populations, such as natural killer (NK) cells and innate lymphoid cells (ILCs), and...

Interferon‐gamma (IFN‐γ) is a cytokine that plays an important role in inducing and modulating an array of immune responses. Cellular responses to IFN‐γ are mediated by its heterodimeric cell‐surface receptor (IFN‐γR), which activates downstream signal transduction cascades, ultimately leading to the regulation of gene expression.

2020年6月11日 · Signalling by the IFNγ receptor activates the Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1) pathway to induce the expression of classical interferon-stimulated genes that have key immune effector functions.

Interferon-gamma (IFN-gamma) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding of IFN-gamma ligand, receptor, signal transduction, and cellular effects with a focus on macrophage respo …

2025年2月8日 · Title: Cholesterol promotes IFNG mRNA expression in CD4(+) effector/memory cells by SGK1 activation. IL-17 and IFN-gamma-producing Respiratory Tissue-Resident Memory CD4 T Cells Persist for Decades in Adults Immunized as …

Interferon-gamma (IFNG) is a pleiotropic cytokine that modulates both innate and adaptive immune networks; it is the most potent activator of macrophages and a signature cytokine of activated T lymphocytes.

Interferon-γ (IFN-γ) is a cytokine whose biological activity is conventionally associated with cytostatic/cytotoxic and antitumor mechanisms during cell-mediated adaptive immune response. Interferon-γ (IFN-γ) can be used for the research of a variety of malignancies. - MedChemexpress Biology Dictionary.

Crystallographic structure of a 3:2 complex of the IFN-γ receptor alpha chain (IFNGR1) (green, cyan, and green/cyan) and the IFN-γ ligand (red and orange). [1] The interferon-gamma receptor (IFNGR) protein complex is the heterodimer of two chains: IFNGR1 and IFNGR2. It binds interferon-γ, the sole member of interferon type II.