Interferon-stimulated gene factor 3 (ISGF3) is the ligand-dependent transcriptional activator that, in response to interferon treatment, is assembled in the cell cytoplasm, is translocated to the nucleus, and binds the consensus DNA site, the interferon-stimulated response element.

2019年7月2日 · We show that interferons (IFN) switch murine macrophages from resting-state to induced gene expression by alternating subunits of transcription factor ISGF3.

ISGF3, a tri-merized complex formed by STAT1, STAT2 and IRF9, recognizes the ISRE motif (TTTCNNTTTC) and induces a group of antiviral genes expression. The other complex formed by STAT1 homodimers binds to GAS motif and mainly active pro-inflammatory genes expression.

We show that interferons (IFN) switch murine macrophages from resting-state to induced gene expression by alternating subunits of transcription factor ISGF3.

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. ISGF-3 is a multiprotein transcription factor that is very quickly activated in the cell cytoplasm only after attachment of interferon alpha to the cell surface.

In addition to the canonical ISGF3 and non-canonical STAT2/IRF9 complexes, evidence is emerging of the role of their unphosphorylated counterparts in IFN-dependent and -independent ISG transcription. To better understand the relation between ISGF3 ...

2017年4月25日 · Interferon (IFN)–stimulated genes (ISGs) are antiviral effectors that are induced by IFNs through the formation of a tripartite transcription factor ISGF3, which is composed of IRF9 and phosphorylated forms of STAT1 and STAT2.

1992年8月8日 · ISGF-3 is a multiprotein transcription factor that is very quickly activated in the cell cytoplasm only after attachment of interferon alpha to the cell surface.

2015年4月20日 · Immune response regulators IRF3 and ISGF3 bind to and activate an overlapping set of target genes, but IRF3 specificity is critical in activating IFNβ. Keywords: pathogen response, gene expression, interferon, feed-forward loop, mathematical modeling.

2015年8月8日 · In this report, we demonstrate that the level of unphosphorylated IFN-stimulated gene factor 3 (U-ISGF3), not ISGF3, is increased by endogenous IFN-λs and IFN-β in HCV-infected hepatocytes and livers, leading to persistent activation of a set of ISGs.