IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity.

2025年3月30日 · IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Inflammatory Bowel Disease 14 and Systemic Lupus Erythematosus 10. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Toll-like receptor signaling pathway.

Interferon regulatory factor 5 (IRF5) belongs to a family of transcription factors, originally implicated in antiviral responses and interferon production. However, studies conducted in different laboratories over the last decade have placed IRF5 as a central regulator of the inflammatory response.

IRF5 是一种关键的转录因子，通过协调 I 型干扰素 (IFN) 基因（包括 IFNA 和 INFB）以及内溶酶体 Toll 样受体（TLR7、TLR8 和 TLR9）下游炎症细胞因子的激活，在先天免疫中发挥关键作用。 它通过与 I 型 IFN 基因和 IFN 刺激基因 (ISG) 启动子中的干扰素刺激反应元件 (ISRE) 结合，作为 I 型 IFN 基因和 IFN 刺激基因 (ISG) 转录的关键调节因子。 值得注意的是，IRF5 有效激活 IFN-β (IFNB) 和 IFN-α (IFNA) 基因，通过 TLR 激活、MyD88 依赖性途径介导它们的诱导。 IRF5 在 …

2024年11月28日 · IRF5已被证明是各种SLE小鼠模型中疾病发展所必需的，可作为SLE的治疗靶点。 IRF5在SLE患者中异常表达和激活，并通过诱导I型干扰素、促炎细胞因子的表达，调节自身抗体的产生进而影响多种致病途径，具有 不同的 发病机制。

2024年1月1日 · This review serves to summarize the literature regarding the role of IRF5 in malignant transformation, cancer progression, association with prognosis and outcome, as well as the mechanisms by which IRF5 is activated or inactivated in malignancies.

2024年10月9日 · Interferon regulatory factors (IRFs) constitute a comprehensive category of transcription factors initially identified as regulators of type I interferon (IFN-I) and...

2018年9月10日 · IRF5 is a key factor in defining the inflammatory macrophage phenotype. IRF5 is highly expressed in not only monocytes and macrophages but also in B cells and dendritic cells. Its expression in macrophages can be upregulated in response to the inflammatory environment and, in particular, to the stimulation with GM-CSF and IFN-gamma [6, 8].

干扰素调节因子 5： 该基因编码干扰素调节因子 (IRF) 家族的一个成员，该家族是一组具有不同作用的转录因子，包括病毒介导的干扰素激活以及细胞生长、分化、凋亡和免疫系统活性的调节。 IRF 家族成员的特征是包含色氨酸 (W) 重复序列的保守 N 端 DNA 结合域。 替代启动子的使用和替代剪接会导致多个转录变体，而 30-nt 插入缺失多态性 (SNP rs60344245) 会导致 10-aa 片段丢失。 [RefSeq 提供，2016 年 12 月]

2016年8月2日 · IRF5 was first identified and characterized as a transcriptional regulator of type I interferon expression after virus infection. In addition to its critical role (s) in the regulation and...