
Inhibition of IL-11 signalling extends mammalian healthspan and ...
2024年7月17日 · As mice age, IL-11 is upregulated across cell types and tissues to regulate an ERK–AMPK–mTORC1 axis to modulate cellular, tissue- and organismal-level ageing …
Understanding interleukin 11 as a disease gene and therapeutic …
Interleukin 11 (IL11) is an elusive member of the IL6 family of cytokines. While initially thought to be a haematopoietic and cytoprotective factor, more recent data show instead that IL11 is …
Scientists discover switching off inflammatory protein leads to …
2024年7月17日 · Scientists at the Medical Research Council Laboratory of Medical Science and Imperial College London have discovered that 'switching off' a protein called IL-11 can …
Interleukin-11: Review of Molecular, Cell Biology, and Clinical …
1997年6月1日 · Initially characterized as a hematopoietic cytokine with thrombopoietic activity, IL-11 has now been shown to be expressed and have activity in multiple other tissues, including …
Interleukin-11 signaling underlies fibrosis, parenchymal ... - Nature
2020年12月1日 · Interleukin (IL)-11 evolved as part of the innate immune response. In the human lung, IL-11 upregulation has been associated with viral infections and a range of …
The Emerging Role of Interleukin-(IL)-11/IL-11R in Bone …
2023年12月1日 · Interleukin- (IL)-11 is a cytokine involved in hematopoiesis, cancer metastasis, and inflammation. IL-11 belongs to the IL-6 cytokine family, binding to the complex of …
Structures of the interleukin 11 signalling complex reveal gp130 ...
2023年11月20日 · Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting …
Interleukin-11: A Potential Biomarker and Molecular Therapeutic …
We review the role of interleukin-11 (IL11), a stromal-cell derived pleiotropic cytokine with profibrotic and cellular remodeling properties, as a potential biomarker in NSCLC.
Interleukin-11 in Pathologies of the Nervous System
2023年3月30日 · Interleukin 11 (IL-11) was discovered in 1990 in fibrocyte-like bone marrow stromal cells, but there has been increased interest in this cytokine in recent years. IL-11 has …
Understanding interleukin 11 as a disease gene and therapeutic
2023年12月13日 · Interleukin 11 (IL11) is an elusive member of the IL6 family of cytokines. While initially thought to be a haematopoietic and cytoprotective factor, more recent data show …
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