Hematopoietic stem cell - Wikipedia
Hematopoietic stem cells are essential to haematopoiesis, the formation of the cells within blood. Hematopoietic stem cells can replenish all blood cell types (i.e., are multipotent) and self-renew. A small number of hematopoietic stem cells can expand to generate a very large number of daughter hematopoietic stem cells.
Haematopoietic stem cells: past, present and future
2017年2月6日 · Haematopoietic stem cells (HSC) are the architects of definitive haematopoiesis, that is, blood cell production that occurs continuously during the life of an organism.
Hematopoietic stem cells: concepts, definitions, and the new reality
Hematopoietic stem cell (HSC) research took hold in the 1950s with the demonstration that intravenously injected bone marrow cells can rescue irradiated mice from lethality by reestablishing blood cell production. Attempts to quantify the cells ...
The role of the haematopoietic stem cell niche in development …
2024年9月10日 · Haematopoietic stem cells (HSCs) are rare, self-renewing cells that reside in the mammalian adult bone marrow and generate all blood cells 1. HSCs are the most primitive haematopoietic...
Hematopoietic Stem Cells - PMC - PubMed Central (PMC)
Hematopoietic stem cells (HSCs) are multipotent precursors that have self-renewal capacity and the ability to regenerate all of the different cell types that comprise the blood-forming system (Bonnet, 2002; McCulloch and Till, 2005).
Haematopoietic stem cells - Latest research and news - Nature
6 天之前 · Haematopoietic stem cells are progenitor cells that have the ability to both generate all types of blood cells, including those of the myeloid and lymphoid lineages, and to replace...
Development of the hematopoietic system: expanding the ... - Cell …
2023年7月20日 · Hematopoietic stem cells (HSCs) give rise to nearly all blood cell types and play a central role in blood cell production in adulthood. For many years it was assumed that these roles were similarly responsible for driving the formation of the hematopoietic system during the embryonic period.
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology - Cell …
2008年2月22日 · Hematopoietic stem cells (HSCs) reside as rare cells in the bone marrow in adult mammals and sit atop a hierarchy of progenitors that become progressively restricted to several or single lineages (Orkin, 2000).
Hematopoietic Stem Cells: The Paradigmatic Tissue-Specific Stem Cell
Hematopoietic stem cells (HSCs) are arguably the most well-characterized tissue-specific stem cell, with decades of basic research and clinical application providing not only a profound understanding of the principles of stem cell biology, but also of its potential pitfalls.
Emerging insights into epigenetics and hematopoietic stem cell ...
2024年11月6日 · The bone marrow microenvironment is composed of several different kinds of cell types including hematopoietic stem cell progenitors, osteoblasts, immune cells, osteoclasts, and perivascular cells [13, 14].Primitive hematopoietic cells undergo trafficking to the specific vascular regions of the bone marrow where CXCL12 and E-selectin are abundant.