H3K9ac is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the acetylation at the 9th lysine residue of the histone H3 protein. The H3K9 histone has two jobs.

2023年2月20日 · These findings highlight epigenetic reprogramming through H3K9ac and H3K14ac as a novel approach for driving neuron-fate-induction of GBM cells.

Based on H3K4me3, H3K9ac, H3K27ac, H3K27me3 and H3K9me3 histone tags, respectively, we investigated 25,075 human genes and 3121 molecular pathways.

2024年1月30日 · Here, we profiled the genome-wide landscapes of H3K9ac for paired adjacent normal (Nor), primary ESCC (EC) and metastatic lymph node (LNC) esophageal tissues from three ESCC patients. Compared to...

2017年9月1日 · Two histone marks on histone H3, lysine 4 trimethylation (H3K4me3) and lysine 9 acetylation (H3K9ac), co-localize on active gene promoters and are associated with active transcription. H3K4me3 can promote transcription initiation, yet the functional role of H3K9ac is much less understood.

2018年12月17日 · We conducted an epigenome-wide association study using the histone 3 lysine 9 acetylation (H3K9ac) mark in 669 aged human prefrontal cortices; in contrast with amyloid-β, tau protein burden had...

2012年8月24日 · Genome-wide H3K9ac and H3K14ac show very high correlation between each other as well as with other histone marks (such as H3K4me3) suggesting a coordinated regulation of active histone marks.

2019年9月1日 · To narrow down which P300-mediated lysine acetylation takes part in gata4 transcription, we performed ChIP using antibodies against H3ac, H3K4ac, H3K9ac, and H3K27ac, followed by qPCR using primers targeting gata4 promoters in order to detect the acetylation state of histones in the gata4 promoters.

2021年1月7日 · Here, we examined genome-wide H3K9ac during SCNT embryo development and found that aberrant H3K9ac regions resulted in reduced 2-cell genome activation. TSA treatment largely corrects aberrant acetylation in SCNT embryos with an efficiency that is dictated by the native epigenetic environment.

In the current study, we explored the roles of H3K4me3, H3K36me3, and H3K9ac modifications in the epigenomic regulation of gene expression in Paulownia during infection by the PaWB phytoplasma and recovery from the disease.