组蛋白h2ax是h2a的变体，在核小体中取代传统的h2a。 紫外线灯等辐射可导致 DNA 损伤，在损伤后几分钟内，组蛋白H2AX的Ser139 位点会发生快速磷酸化。 因此，第139位丝氨酸磷酸化的H2AX，被命名为gamma H2A.X，已被广泛用作DNA双链断裂（DSBs）的标记，来指示双 …

H2A histone family member X (usually abbreviated as H2AX) is a type of histone protein from the H2A family encoded by the H2AFX gene. An important phosphorylated form is γH2AX (S139), which forms when double-strand breaks appear.

Abstract: H2AX is one of the common variants of the histone H2A family, and its phosphorylation refers to the process of phosphorylation modification of histone H2AX in mammalian cells at its C-terminal Serine 139 to form histone H2AX phosphorylation (γH2AX). Currently, γH2AX can be detected by immunofluorescence, flow cytometry and ...

2010年2月4日 · Phosphorylation of the Ser-139 residue of the histone variant H2AX, forming γH2AX, is an early cellular response to the induction of DNA double-strand breaks.

组蛋白2a变异体（h2ax）在dna双链断裂损伤时可以发生不同的翻译后修饰，包括磷酸化、乙酰化、甲基化和泛素化。 当细胞发生DNA损伤时，H2AX的氨基酸保守序列发生磷酸化。

碧云天生产的DNA损伤检测试剂盒(γ-H2AX免疫荧光法)，英文名为DNA Damage Assay Kit by γ-H2AX Immunofluorescence，是通过免疫荧光染色检测DNA损伤标记物γ-H2AX (即磷酸化的H2AX)的含量以确认DNA是否损伤的检测试剂盒。

2025年3月30日 · H2AX (H2A.X Variant Histone) is a Protein Coding gene. Diseases associated with H2AX include Nijmegen Breakage Syndrome and Large B-Cell Lymphoma. Among its related pathways are RNA Polymerase I Promoter Opening and Packaging Of Telomere Ends. An important paralog of this gene is H2AC16.

H2AX is a histone H2A variant that constitutes 2–25% of mammalian histone H2A depending on the organism and cell type (Redon et al. 2002; Rogakou et al. 1998).

2024年6月1日 · By delineating the pathways that lead to H2AX phosphorylation and its roles in apoptosis and cell cycle control, we highlight the significance of H2AX as both a prognostic tool and a focal point for therapeutic intervention, offering insights into its utility in enhancing the efficacy of cancer treatments.

2020年4月8日 · 回头看看，关于DNA损伤修复的文章分享了好几篇，索性又扒了扒老文章，找到了一篇17年的nature子刊，看的是DNA损伤修复过程中的γH2AX，具体内容如下：