Granzyme B is a serine protease that in humans is encoded by the GZMB gene. [5] . Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells.

Granzyme B (GrB) is one of the serine protease granzymes most commonly found in the granules of natural killer cells (NK cells) and cytotoxic T cells. It is secreted by these cells along with the pore forming protein perforin to mediate apoptosis in target cells.

2025年3月30日 · GZMB (Granzyme B) is a Protein Coding gene. Diseases associated with GZMB include Stevens-Johnson Syndrome and Peripheral T-Cell Lymphoma. Among its related pathways are Signaling by ALK in cancer and Programmed Cell Death.

2025年2月8日 · Title: A robust gene prognostic index composed of GZMB, IRF1, and TP63 can stratify the risk of two metastatic urothelial carcinoma cohorts based on immune checkpoint blockade therapy.

2024年8月23日 · Widely recognized as intracellular mediators of cell death, granzymes, particularly granzyme B (GzmB), also accumulate in the extracellular milieu of tissues with age, contributing to chronic tissue injury, inflammation, and impaired healing.

GZMs are a family of serine proteases that were originally identified in the cytotoxic granules of cytotoxic T and NK cells. The most-abundant and best-characterized members, GZMA and GZMB, have been found in several immune and, more recently, non-immune cell types.

2021年1月12日 · Here, we explore the role of the immune cell-secreted serine protease, granzyme B, in pemphigoid disease pathogenesis using three independent murine models. In all models, granzyme B knockout or...

2013年8月2日 · Granzyme B (GzmB) is a serine protease expressed during chronic inflammation that, in conjunction with perforin, has a well-established role in initiating apoptotic cell death. GzmB is also...

2022年5月2日 · The chemical design of activity-sensing reporters of granzyme B (GzmB) represents a potentially effective strategy for monitoring the cytotoxic activity of CD8+ T cells in cancer.

2022年11月9日 · Our study support the involvement of GzmB-expressing CD8+ T cells in the inflammatory response in patients with NMOSD and provide a potential biomarker for disease immunotherapy effectiveness and disability progression.