
Full-length GSDME mediates pyroptosis independent from …
2024年7月12日 · We here discovered a form of pyroptosis mediated by full-length (FL) GSDME without proteolytic cleavage. Intense ultraviolet-C irradiation-triggered DNA damage activates nuclear PARP1, leading to...
Gasdermin E suppresses tumour growth by activating anti-tumour ... - Nature
2020年3月11日 · GSDME expression enhances the phagocytosis of tumour cells by tumour-associated macrophages, as well as the number and functions of tumour-infiltrating natural-killer and CD8 + T lymphocytes....
GSDME-mediated pyroptosis promotes the progression and
2023年2月18日 · GSDME expression is upregulated in atherosclerotic lesions, and GSDME deficiency suppresses pyroptosis-related inflammation and decreases the development of atherosclerosis.
The multifaceted roles of GSDME-mediated pyroptosis in cancer ...
Gasdermin E (GSDME), a crucial component of the gasdermin (GSDM) family proteins, has the ability to convert caspase-3-mediated apoptosis to pyroptosis of cancer cells and activate anti-tumor immunity.
GSDME and its role in cancer: From behind the scenes to the ... - PubMed
2021年6月15日 · Our review only focuses on GSDME and summarizes the current knowledge and most recent advances on GSDME's role in cancer formation, its potential as a biomarker in cancer and on its promising role in immunotherapies and antitumor immune response.
Gasdermin E suppresses tumour growth by activating anti-tumour ... - PubMed
2020年3月20日 · GSDME expression is suppressed in many cancers, and reduced GSDME levels are associated with decreased survival as a result of breast cancer 2,6, suggesting that GSDME might be a tumour suppressor. Here we show that 20 of 22 tested cancer-associated GSDME mutations reduce GSDME function.
GSDME-mediated pyroptosis contributes to chemotherapy …
2024年12月19日 · Herein, using human platelets and platelets from mice lacking gasdermin E (GSDME), we show that GSDME is functionally expressed in anucleate platelets, and that GSDME-mediated pyroptosis, a newly identified form of cell death in mammalian nucleated cells, contributes to platelet hyperactivity in cisplatin-based chemotherapy.
Gasdermin E: A Prospective Target for Therapy of Diseases
In this review, we emphasize the PCD mediated by GSDME, summarize the key roles of GSDME in both cancer and non-cancer diseases, and describe the potential therapeutic approaches targeting GSDME, so as to provide directions for the targeted therapy in the future.
GSDME : A Potential Ally in Cancer Detection and Treatment
2021年1月6日 · Gasdermin E (GSDME) is an executioner of caspase-3 mediated regulated pyroptosis, and as such plays an important role in several cancers. Recent findings highlighted the potential of GSDME as a biomarker that can be …
The caspase-3/GSDME signal pathway as a switch between
2020年10月28日 · GSDME-mediated pyroptosis is correlated with the side effects of chemotherapy and anti-tumor immunity. This article mainly reviews the caspase-3/GSDME signal pathway as a switch between...