GSDMB Gene - GeneCards | GSDMB Protein | GSDMB Antibody
2025年3月30日 · GSDMB (Gasdermin B) is a Protein Coding gene. Diseases associated with GSDMB include Childhood-Onset Asthma and Oral Squamous Cell Carcinoma. An important …
Structural mechanisms for regulation of GSDMB pore-forming …
2023年3月29日 · The cryo-EM structure of the GSDMB pore reveals mechanisms by which GSDMB pore-forming activity is regulated by pathogenic bacteria and mRNA splicing.
Distinct GSDMB protein isoforms and protease cleavage processes ...
2023年3月11日 · Gasdermin (GSDM)-mediated pyroptosis is functionally involved in multiple diseases, but Gasdermin-B (GSDMB) exhibit cell death-dependent and independent activities …
Role of GSDMB in Pyroptosis and Cancer - PMC - PubMed Central …
Gasdermin B (GSDMB) belongs to the gasdermin (GSDM) family which may adopt different mechanisms of intramolecular domain interactions to modulate their lipid-binding and pore …
GSDMB is increased in IBD and regulates epithelial …
2022年1月20日 · Gasdermin B (GSDMB) is currently the least studied, and while its association with genetic susceptibility to chronic mucosal inflammatory disorders is well established, little …
GSDMB gasdermin B [Homo sapiens (human)] - Gene - NCBI
2024年12月10日 · Title: GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis. Structural and functional insights …
Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal ...
2021年5月21日 · Gasdermin B (GSDMB) belongs to a large family of pore-forming cytolysins that execute inflammatory cell death programs. While genetic studies have linked GSDMB …
Structural basis for GSDMB pore formation and its targeting by
2023年3月29日 · Here, we report the cryogenic electron microscopy structures of human GSDMB in complex with Shigella IpaH7.8 and the GSDMB pore. The structure of the GSDMB–IpaH7.8 …
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to …
2020年4月16日 · Zhou et al. show that granzyme A cleaves and activates gasdermin B (GSDMB), a central player in the highly inflammatory cell death process known as pyroptosis (see the …
Gasdermin‐B (GSDMB) takes center stage in antibacterial defense ...
2023年11月23日 · To exploit GSDMB antibiotic activity for gram-negative bacteria infection, it is essential first to characterize how GSDMB variants might differentially target internal and …
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