2025年3月30日 · GAS6 (Growth Arrest Specific 6) is a Protein Coding gene. Diseases associated with GAS6 include Mesangial Proliferative Glomerulonephritis and Lupus Erythematosus. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

GAS6 (growth arrest-specific 6) belongs structurally to the family of plasma vitamin K-dependent proteins. GAS6 has a high structural homology with the natural anticoagulant protein S, sharing the same modular composition and having 40% sequence identity.

It is accepted that the Gas6/TAM pathway can promote the malignant transformation of various types of cancer cells. Gas6 has the highest affinity for Axl, an important member of the TAM receptor family. Knockdown of the TAM receptors Axl …

Our data propose GAS6 as an independent predictor of poor survival, suggesting GAS6, both on the mRNA and on the protein level, as a potential biomarker for ovarian cancer. Gas6 was uniquely upregulated in either endothelial/mesangial cells or podocytes in IgA nephropathy.

2017年7月1日 · GAS6 regulates thrombin signaling on endothelial cells supporting CCL2-mediated recruitment of proinflammatory CCR2 hi CX3CR1 lo monocytes by increasing PSGL-1 expression, thus augmenting thrombus growth in the IVC thrombosis.

2017年3月23日 · Gas6 has a critical role in the development of multiple types of cancers, including pancreatic, prostate, oral, ovarian and renal cancers. Acute myelocytic leukaemia (AML) is a Gas6-dependent...

2024年12月9日 · Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents. Hsiao FC, et al. J Clin Endocrinol Metab, 2013 Feb. PMID 23341490. Serum levels of growth arrest specific protein 6 are increased in preeclampsia. Stepan H, et al. Regul Pept, 2013 Mar 10.

Growth arrest-specific gene 6 (Gas6), identified in 1995, acts as the ligand to the Axl/Tyro3 family of tyrosine kinase receptors and exerts mitogenic activity when bound to these receptors. Overexpression of the Axl/Tyro3 receptor family has been found in …

Recombinant human Gas6 protein and inhibitor TP-0903 were used to activate and inhibit the Gas6/Axl signaling pathway, respectively. The results revealed that Gas6 and Axl expression level was increased in human lung adenocarcinoma tissues compared with adjacent healthy tissues.

2024年1月25日 · Clinical resource with information about GAS6, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.