GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 family and involved in the folding and assembly of proteins in the ER. [6] The level of BiP is strongly correlated with the amount of secretory proteins (e.g. IgG) within the ER. [19]

2023年11月11日 · 简介 葡萄糖调节蛋白 78kd (grp78) 是一种分子伴侣，也是 er 应激反应的主要调节因子，该反应由多种干扰 er 中蛋白质折叠的条件触发。 在内质网应激时，GRP78 会激活未折叠蛋白反应 (UPR)，其目的是清除未折叠蛋白并恢复内质网稳态。

GRP78/BiP is a major endoplasmic reticulum (ER) chaperone protein critical for protein quality control of the ER, as well as controlling the activation of the ER-transmembrane signaling molecules. Through creation of mouse models targeting the Grp78 allele, the function of GRP78 in development and disease has been investigated. These led to the ...

The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum (ER)-resident molecular chaperone. GRP78 is a member of the 70 kDa heat shock family of proteins involved in correcting and clearing misfolded proteins in the ER. In response to cellular stress, GRP78 escapes from the ER and mo …

2019年2月12日 · Glucose regulatory protein 78 (GRP78), the master regulator of the UPR, plays a role in proliferation, invasion, and metastasis in cancer.

Glucose-Regulated Protein 78 (GRP78) is a chaperone heat shock protein that has been intensely studied in the last two decades. GRP78 is the master of the unfolded protein response (UBR) in the Endoplasmic Reticulum (ER) in normal cells. GRP78 force the unfolded proteins to refold or degrade using cellular degradation mechanisms. Scope

2019年6月1日 · GRP78 is the master of the unfolded protein response (UBR) in the Endoplasmic Reticulum (ER) in normal cells. GRP78 force the unfolded proteins to refold or degrade using cellular degradation mechanisms. Scope: Under stress, the overexpression of GRP78 on the cell membrane mediates the vast amount of disordered proteins. Unfortunately, this ...

grp78 bip (hspa5)靶点介绍及实验小贴士靶点介绍助您了解其蛋白功能，蛋白特性，蛋白定位及异构体和翻译后修饰等特质。同时列举了实用的wb实验小贴士，助您实验成功。

grp78 在癌细胞和血管生成内皮细胞的表面过度表达，这使其成为不同类型的肽和抗体的有希望的靶标，可用于靶向癌症治疗或成像。 在这篇综述中，我们讨论了肿瘤细胞中细胞表面 GRP78 (csGRP78) 的生物学过程、功能重要性和易位机制。

2021年5月7日 · The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum (ER)-resident molecular chaperone. GRP78 is a member of the 70 kDa heat shock family of proteins involved in correcting and clearing misfolded proteins in the ER.