Cytochrome c oxidase (cytochrome aa3, ferrocytochrome c, oxygen oxidoreductase, EC 1.9.3.1) is the terminal enzyme or complex IV of the mitochondrial electron transport chain, without which oxidative metabolism cannot be carried to completion (Wikström et al., 1981).

Cyt c is an evolutionarily conserved nuclear-encoded mitochondrial protein, which contains 104 amino acids in mammals. It is highly positively charged with a pI of 9.6. Cyt c is essential for aerobic energy production and Cyt c knockout mice die around midgestation (Li et al., 2000a).

2006年5月5日 · Cyt c, a peripheral protein of the mitochondrial inner membrane (IM), functions as an electron shuttle between complex III and complex IV of the respiratory chain and its activity is...

Cytochrome c is one of the mitochondrial proteins that is released into the cytosol when the cell is activated by an apoptotic stimulus. In the cytosol, cytochrome c engages the apoptotic...

In the Electron Transport Chain, cytochrome c transfers one electron at a time via its heme group from the third complex of the electron transport chain, cytochrome bc1, to the fourth complex of the electron transport chain, cytochrome c oxidase.2. Cytochrome c contains a heme iron metal center that is essential to its function.

2024年3月23日 · We summarize how posttranslational modifications of cytochrome c (e.g., phosphorylation, acetylation, tyrosine nitration, and oxidation), binding proteins (e.g., HIGD1A, CHCHD2, ITPR1, and...

Cytochrome c is a well-known mitochondrial protein that fulfills life-supporting functions by transferring electrons to the respiratory chain to maintain ATP production. However, during the activation of apoptotic machinery, it is released from ...

The heme protein cytochrome c (Cyt c) is one of the most promising proapoptotic proteins for cancer therapy. Its participation in apoptosis in the cytosol is juxtaposed with its pivotal role at the mitochondrial inner membrane in cellular respiration as part of the electron transport chain (ETC).

2020年4月1日 · We here discuss the regulation of Cyt c, focusing on phosphorylation and its effects on respiration and apoptosis. Based on recent data we propose, as a new model, that Cyt c phosphorylation controls overall flux in the ETC and apoptosis, which determines the balance between ATP, ROS, and apoptosis.

Cytochrome c (CYT c) is a soluble redox-active heme protein that transfers electrons from complex III to complex IV in the cyanide-sensitive mitochondrial respiratory pathway. CYT c biogenesis is a complex process that requires multiple …