The cGAS–STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, in response, trigger expression of inflammatory genes that can lead to senescence [1] or to the activation of defense mechanisms. DNA is normally found in the nucleus of the cell.

Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), belonging to the nucleotidyltransferase family, is a cytosolic DNA sensor that activates a type-I interferon response. It is part of the cGAS-STING DNA sensing pathway. It binds to microbial DNA as well as self DNA that invades the cytoplasm, and catalyzes cGAMP synthesis.

2021年4月30日 · Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special...

2025年1月7日 · In this Review, we describe recent insights from structural studies that have helped to elucidate the molecular mechanisms of the cGAS–STING signalling cascade and we discuss how the...

2020年5月18日 · Here, we review the molecular mechanisms and cellular functions underlying cGAS–STING activation and signalling, particularly highlighting the newly emerging diversity of this signalling pathway...

2025年2月26日 · Cyclic GMP-AMP synthase (cGAS), a critical cytosolic DNA sensor initiating innate immune responses in the presence of cytosolic DNA, is increasingly recognized as a promising therapeutic target for ulcerative colitis (UC). Here, we reported the design, synthesis, structure–activity relationship exploration and biological evaluation of a novel class of CRBN …

4 天之前 · Schematic of the cGAS‒STING pathway. Canonical cGAS-STING Pathway. Cytosolic double-stranded DNA (dsDNA), originating from viruses, bacteria, necrotic cells, or other sources, activates cGAS, which catalyzes the synthesis of cGAMP from ATP and GTP. cGAMP subsequently binds to and activates STING, which, upon activation, recruits TBK1 and IKK.