2019年4月19日 · 以B细胞为例，外周血B细胞可通过免疫球蛋白M（IgM）、IgD、CD10、CD19、CD24、CD27和CD38的表达量不同区分为8个连续分化的亚群，依次为 Immature B 、 T1 Transitional B 、 T2 Transitional B 、 T3 Transitional B 、 Naive B 、 Unswitched Memory B 、 Switched Memory B 、 Plasmablast ，详见下图：

2018年10月21日 · CD24 expression on pro-B cells plays a role in B cell selection and development in the bone marrow. We previously detected higher CD24 expression and frequency within IgD+ naïve and memory B cells in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) compared with age-matched healthy controls (HC).

2018年10月22日 · CD24 expression on pro-B cells plays a role in B cell selection and development in the bone marrow. We previously detected higher CD24 expression and frequency within IgD+ naïve and memory B cells in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) compared with age-matched …

2017年8月17日 · The CD24 cell surface receptor promotes apoptosis in developing B cells, and we recently found that it induces B cells to release plasma membrane-derived, CD24-bearing microvesicles...

CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils [6] and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a …

2023年10月30日 · CD24 antibody treatment to reduce MZB cells and IgM in a hyperlipidemic humanized mouse model provides the evidence that MZB cells protect against vascular inflammation. Consistent with these...

2021年12月15日 · Engaging CD24 on pro– or pre–B cells with anti-CD24 Abs leads to apoptosis and CD24 engagement in mature splenic B cell blocks CD40-induced proliferation (22, 23). We have also found that Ab-mediated engagement of CD24 induces apoptosis in the immature murine WEHI-231 B cell line, demonstrating that this cell line models the CD24-mediated ...

2019年10月15日 · In this study, we report that the frequency of IL-10-producing Bregs in human peripheral blood, spleens, and tonsils is similar, but they display heterogenous surface phenotypes. Nonetheless, CD24 hi CD38 hi transitional B cells (TBs) and CD24 hi CD27 + B cells (human equivalent of murine B10 cells) are the major IL-10-producing B cells.

Here, we describe the preliminary characterization of a proposed new population of memory B cells, defined as CD19 + CD38 − CD24 −, which we find at higher frequencies in the elderly but less so in CO than healthy age-matched random controls.

1991年8月15日 · CD24 is a signal-transducing molecule on the surfaces of most human B cells that can modulate their response to activation signals by antagonizing IL-induced differentiation into antibody-forming cells and inducing proliferation in combination with …