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We recently determined that CBSX proteins, which have only one pair of cystathionine β-synthase (CBS) domains, directly regulate the activation of thioredoxins and thereby control cellular H2O2 levels and modulate both plant development and growth. The Arabidopsis genome contains six CBSXs, and thes …

2023年4月23日 · Highlights • NADPH-thioredoxin reductase C (NTRC) is a key factor of chloroplast redox regulation. • NTRC activity was suppressed by cystathionine-β-synthase X (CBSX) proteins. • CBSX proteins required AMP to exert inhibitory effects on NTRC. • This study shows a novel mechanism for controlling NTRC activity.

Possible candidate signal molecules/sensor relay proteins are the adenosine-containing metabolites and proteins, denoted CBSXs, which are characterized by containing only one pair of cystathionine β-synthase (CBS) domains—and no other protein domains.

2021年2月15日 · The chloroplast-localized cystathionine β-synthase X (CBSX) proteins CBSX1 and CBSX2 have been proposed as modulators of thioredoxins (Trxs). In this study, the contribution of CBSX proteins to the redox regulation of thiol enzymes in the chloroplast Trx system was evaluated both in vitro and in vivo.

Here, we show that proteins consisting of a single cystathionine β-synthase (CBS) domain pair stabilize cellular redox homeostasis and modulate plant development via regulation of Trx systems by sensing changes in adenosine-containing ligands.

2023年11月13日 · To investigate the mechanism underlying the oxidation of CF 1 γ and other chloroplast redox-regulated enzymes in the dark, we characterized the Arabidopsis cbsx2 mutant, which was isolated based on its altered NPQ (non-photochemical quenching) induction upon …

2013年1月4日 · In this study, crystal structures of full-length CBSX1 and the internal loop deleted (Δloop) form are reported at resolutions of 2.4 and 2.2 Å, respectively. The structures of CBSX1 show that they form anti-parallel dimers along their central twofold axis and have a unique ∼155° bend along the side.

胱硫醚-β-合酶 X (CBSX) 蛋白先前已被证明与 NTRC 物理相互作用。 基于这些观察结果，本研究在体外对拟南芥中CBSX 蛋白与 NTRC 之间的功能相互作用进行了生物化学研究。

2020年5月1日 · In this study, we identified a CBS domain-containing protein, CBSX3, and found that CBSX3 activates o-type thioredoxin (Trx-o2) in mitochondria. In addition, we found that Trx-o2 interacts with SDH1, a subunit of ETC complex II.