CXCL9, also known as monokine induced by gamma interferon (MIG), is located on human chromosome 4, and is induced by IFN-γ but not by IFN-α/β. CXCL10 and CXCL11 are also located on human chromosome 4. CXCL9 predominantly mediates lymphocytic infiltration to the focal sites and suppresses tumor growth.

CXCL9 has a versatile and controversial role in tumors, and accumulating evidence suggests that CXCL9 is closely associated with the prognosis of tumor patients.

2025年3月30日 · CXCL9 (C-X-C Motif Chemokine Ligand 9) is a Protein Coding gene. Diseases associated with CXCL9 include Proliferative Glomerulonephritis and Paracoccidioidomycosis. Among its related pathways are MIF Mediated Glucocorticoid Regulation …

2025年3月8日 · Title: CXCL9 may serve as a potential biomarker for primary Sjögren's syndrome with extra-glandular manifestations. Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicators.

This review for the first time presents the most comprehensive summary for the role of CXCL9 in different types of tumors, and demonstrates its contradictory role of CXCL9 in tumor progression. Altogether, this is a useful resource for researchers investigating therapeutic opportunities for …

2023年7月1日 · CXCL9 participates in metabolic-associated fatty liver disease via facilitating the imbalance of Treg/Th17 cells with interferon-gamma, providing another new direction to treat this disease .

2019年6月18日 · In this issue of Immunity, Chow et al. (2019) reveal that successful PD-1 immunotherapy requires expression of the CXCR3 chemokine receptor on CD8 + T cells and CXCL9 production by CD103 + dendritic cells (DCs).

The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis).

The aim of this review is to present data from the available literature concerning CXCL9, CXCL10 and CXCL11, as well as their receptor 3 (CXCR3) in selected diseases of the central nervous system (CNS), such as tickborne encephalitis (TBE), neuroborreliosis (NB), Alzheimer's disease (AD), and multip …

2025年3月19日 · CXCL9:SPP1 polarity as an indicator of TME immune activity and prognosis in cancer patients. The CXCL9:SPP1 polarity could serve as an indicator of immune activity within the TME and may hold significance for patient prognosis. A high CXCL9:SPP1 ratio defining TAM polarity suggests a TME enriched with immune activation and anti-tumor factors ...