CD14 (cluster of differentiation 14) is a human protein made mostly by macrophages as part of the innate immune system. [5] [6] It helps to detect bacteria in the body by binding lipopolysaccharide (LPS), a pathogen-associated molecular pattern (PAMP).

CD14，即LPS（Lipopolysaccharide）受体，最初是一种存在于单核细胞、巨噬细胞等细胞表面的白细胞分化抗原，由TODD于1981年首次从人单核细胞表面发现。

CD14（cluster of differentiation 14，分化簇14）是一种细胞表面蛋白质，主要在先天免疫系統的巨噬细胞上表达 [5] ，是最早发现的模式识别受体 [6] ，能参与识别脂多糖（LPS，一种病原相关分子模式）。

CD14(cluster of differentiation 14)原称MY23抗原，是一种表面抗原，属细胞表面糖蛋白家族成员之一。CD14基因编码的蛋白，优先表达于单核/巨噬细胞。CD14是革兰阴性菌内毒素脂多糖LPS和LPS结合蛋白(LBP)复合物的…

The cell surface antigen CD14 is primarily understood to act as a co-receptor for toll-like receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury in macrophages and monocytes. However, roles for CD14 are increasingly ...

2024年12月24日 · CD14 (CD14 Molecule) is a Protein Coding gene. Diseases associated with CD14 include Alagille Syndrome 1 and Croup. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System. Gene Ontology (GO) annotations related to this gene include lipopolysaccharide binding and lipoteichoic acid binding.

2019年8月1日 · Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses. CD14 was first identified as a marker of monocytes to signal intracellular responses upon bacterial encounters. Given the absence of an intracellular tail, CD14 was doubted to have the signaling capacities.

2024年4月2日 · 根据CD14在体内的存在形式，分为存在于细胞表面的膜结合型CD14（membranebound CD14，mCD14）和血浆内的sCD14。 mCD14是一种分子量为5.3万～5.5万的糖蛋白，主要通过糖基磷脂酰肌醇（glycosylphosphatidylinositol，GPI）锚着在细胞膜上，少数mCD14也可通过跨膜肽与细胞膜结合 ...

In this review, we summarize advancements in the basic biology of the CD14 including its structure, binding ligands, signaling pathways, and its roles in the pathogenesis of inflammation, atherosclerosis, tumor and metabolic diseases. We also discuss the therapeutic potential of targeting the CD14 in related diseases.

CD14 是一种糖磷脂酰肌醇锚定的质膜蛋白，在 LPS 介导的 TLR4 激活中具有长期确定的作用；CD14 与 LPS 结合并将 LPS 转移到 TLR4-MD2 复合物，从而启动 myddosome 组装和信号转导（Lipopolysaccharide induces alveolar macrophage necrosis via CD14 and the P2X7 receptor leading to interleukin-1α release.