Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) [5] while other BCL2 family …

The BCL-2 family has four main functions: inhibitory effects (BCL-2, BCL-Xl, BCL-W, BCL2-A1, and MCL-1), activation (BIM and PUMA), effector (BAX and BAK), and sensitization (NOXA). …

Bcl-2 is a 26-kDa protein that is part of a family of proteins involved in regulating cell death. It is located at contact sites between the inner and outer mitochondrial membranes and can inhibit …

We discuss BCL-2 family regulation and how to determine cells’ readiness for apoptosis and anti-apoptotic dependence. Cancer cells often adopt anti-apoptotic defense mechanisms in …

2025年3月28日 · BCL2 (BCL2 Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BCL2 include Follicular Lymphoma and High-Grade B-Cell Lymphoma Double …

Targeting the intrinsic apoptotic pathway regulated by B-cell lymphoma-2 (BCL-2) antiapoptotic proteins can overcome the evasion of apoptosis in cancer cells. BCL-2 inhibitors have evolved …

2019年2月21日 · BCL-2 family members play an integral role in apoptosis, but also contribute to many other cellular functions. Isoforms of almost all of the BCL-2 family members have been …

BCL-2 family proteins have either pro- or anti-apoptotic activities that are crucial for the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy.

2023年7月12日 · In this Review, we revisit the most important advances in the field and integrate them into a new structure–function-based classification of the BCL-2 family members that …

2020年12月4日 · To help understand the potential and limitations of this therapy, this brief review will touch on the history of development of venetoclax, dissect its mechanism of action, and …