Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene [5][6][7] and is involved in the unfolded protein response. ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules. [8] .

2025年3月28日 · ATF6 (Activating Transcription Factor 6) is a Protein Coding gene. Diseases associated with ATF6 include Achromatopsia 7 and Achromatopsia. Among its related pathways are Unfolded Protein Response (UPR) and Alzheimer's disease and miRNA effects.

2024年3月15日 · Activating transcription factor 6 (ATF6), an important signaling molecule in unfolded protein response (UPR), plays a role in the pathogenesis of several diseases, including diseases such as congenital retinal disease, liver fibrosis and ankylosing spondylitis.

Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked to stress to the endoplasmic ...

ATF6 encodes a transcription factor that is anchored in the endoplasmic reticulum (ER) and activated during the unfolded protein response (UPR) to protect cells from ER stress.

ATF6 is a transcriptional regulator of the mammalian UPR and is activated by regulated proteolysis. Interestingly, as ATF6 induces Xbp-1 mRNA expression, coping with ER stress at multiple levels should therefore be possible in mammals.

ATF6 Is Activated by Ischemia/Reperfusion and Is Protective. Soon after the ATF6-MER transgenic mice were developed they were used to determine the role for activated ATF6 in cardiac myocytes, in vivo.

ATF6 is an ER-membrane-bound transcription factor activated by ER stress-induced proteolysis which consists of two closely related factors, ATF6alpha and ATF6beta, in mammals. ATF6alpha but not ATF6beta plays an important role in transcriptional control.

2018年10月19日 · Cardiac myocyte-specific deletion of Atf6 (ATF6 cKO [conditional knockout]) blunted transverse aortic constriction and exercise-induced cardiac myocyte hypertrophy and impaired cardiac function, demonstrating a role for ATF6 in compensatory myocyte growth.

In high glucose culture, beta cell proliferation, but not apoptosis, was increased by overexpression of ORMDL3 levels, likely mediated by its downstream factor ATF6. Mechanistically, ORMDL3 transcriptionally activated ATF6, which was confirmed in a promoter reporter assay.

2018年8月6日 · Tam et al. find that dihydrosphingosine and dihydroceramide, early sphingolipid intermediates, directly activate the mammalian UPR sensor ATF6, via a domain distinct from that targeted by proteotoxic stress, and preferentially activate lipid biosynthetic genes.

2018年5月25日 · Best known for its role in transducing signals linked to stress to the endoplasmic reticulum, the 50 kDa activated form of ATF6 is now emerging as a major regulator of organogenesis and tissue homeostasis.

2025年4月1日 · ATF6 promotes cancer chemoresistance by enhancing survival under stress conditions. It interacts with STAT3, NOTCH1, MAPK, and lysosomal pathways, driving resistance. Targeting ATF6 with compounds like curcumin improves chemotherapy sensitivity.

ATF6 is an endoplasmic reticulum (ER) transmembrane transcription factor that is activated by the ER stress/unfolded protein response by cleavage of its N-terminal half from the membrane. We find that ER stress induces ATF6 to move from the ER to the Golgi, where it is cut in its luminal domain by site 1 protease.

2017年10月13日 · We recently isolated ATF6 as a candidate for mammalian UPR-specific transcription factor. We report here that ATF6 constitutively expressed as a 90-kDa protein (p90ATF6) is directly converted to a 50-kDa protein (p50ATF6) in ER-stressed cells.

We constructed a dynamic model to describe the adaptive UPR signaling network, for which incorporation of all three branches was required to match the data. Our calibrated model suggested that ATF6 shapes the early dynamics of pro-apoptotic CHOP.

ATF6 is a key transcriptional activator of the unfolded protein response (UPR), which allows mammalian cells to maintain cellular homeostasis when they are subjected to a variety of environmental and physiological stresses that target the endoplasmic reticulum (ER).

2025年4月1日 · ATF6 operates as a basic-leucine zipper (bZIP) transcription factor that binds to the consensus ER stress response element (ERSE), regulating the transcription of genes involved in maintaining ER ...

In response to endoplasmic reticulum (ER) stress, activating transcription factor 6 (ATF6), an ER membrane-anchored transcription factor, is transported to the Golgi apparatus and cleaved by site-1 protease (S1P) to activate the unfolded protein response (UPR).

The ChIP-seq results showed that p-STAT3 (Tyr705) protein directly binds with ATF6 promoter, suggesting that STAT3 has a direct regulatory effect on ATF6 in neurons, thus explaining the upstream mechanism of ER stress mediated neuron apoptosis.