Afimoxifene (4-Hydroxytamoxifen, trade name TamoGel) is a new estrogen inhibitor under investigation for a variety of estrogen-dependent conditions, including cyclic breast pain and …

4-hydroxytamoxifen is a selective estrogen receptor modulator. It is currently in the development process to work as a potential breast hyperplasia treatment. Follow these links to do a live 2D …

The goal of this study was to determine the direct, acute effects of Tam, its active metabolite 4-hydroxytamoxifen (4OHT), and related drug raloxifene (Ral) on isolated rat cardiac myocyte …

4-Hydroxytamoxifen Ready Made Solution (cis/trans-4-Hydroxytamoxifen ); 5mg/mL ethanol: isopropanol (95:5); 4-Hydroxytamoxifen is an active metabolite of Tamoxifen; 4 …

Selective estrogen receptor modulators (SERMs) are synthetic molecules that exhibit tissue-specific activities. 4-hydroxytamoxifen (OHT) is a first generation SERM that functions as an …

By using a peptide sensor assay, we have identified the stilbenes diethylstilbestrol (DES), tamoxifen (TAM), and 4-hydroxytamoxifen (4-OHT) as high-affinity ligands for ERRγ. In direct …

4-Hydroxytamoxifen ( (Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ( (Z)-4-Hydroxytamoxifen) induces CRISPR/Cas9 …

We report the development and preclinical testing of a boronic prodrug to orally deliver 4-OHT at therapeutically effective concentrations but at a fraction of the standard tamoxifen dose. A …

4-Hydroxytamoxifen (4-OHT) is a metabolite of the antiestrogen, tamoxifen, in humans and other mammals. Both the Z (trans) and E (cis) 4-OHT isomers are antiestrogens in the immature rat.