Regulation of ERK-MAPK signaling in human epidermis
2015年7月25日 · The skin is largely comprised of keratinocytes within the interfollicular epidermis. Over approximately two weeks these cells differentiate and traverse the thickness of the skin.
MAPK Pathway Involved in Epidermal Terminal Differentiation of …
The MAPK signaling pathway has been shown to play critical roles in epidermal differentiation and skin barrier function [20,21,22,23]. The MAPK signaling pathways can integrate and mediate various signals involved in keratinocyte differentiation, including epidermal growth factor receptor (EGFR), integrin and calcium signaling.
The Complexity of the ERK/MAP-Kinase Pathway and the …
The central role played by the ERK/MAPK pathway downstream of RAS in human neoplasias is best exemplified in the context of melanoma skin cancer. Signaling through the MAPK pathway is crucial for the proliferation of melanocytes, the healthy pigment cells that give rise to melanoma.
The MAPK pathway across different malignancies: - PMC
The MAPK/ERK pathway stimulates cellular proliferation and invasion; however, its activation also can increase cellular apoptosis or antagonize pro-oncogenic input from other signals. The MAPK/ERK pathway demonstrates both oncogene and tumor suppressor effects depending on the tissue-specific tumor microenvironment.
Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier ...
2017年4月21日 · Immunoblotting and immunohistochemistry revealed that phosphorylated-p38 MAPK was increased in the skin and epidermis of IMQ-treated mice (Figures 6a and b).
Regulation of ERK-MAPK signaling in human epidermis
2015年7月25日 · The model demonstrates that the spatial profile of activation for ERK-MAPK signaling components across the epidermis may be maintained in a cell-autonomous fashion by an underlying spatial gradient in calcium signaling.
MAPK/ERK signaling governs the diverging healing outcome of skin …
Immunohistochemistry, bulk and scRNA-seq, loss- and gain-of-function experiments were deployed to assess the role of specific pathways during skin and cartilage regeneration. Results: Spiny mice exhibited MAPK/ERK signaling-mediated asymmetric regeneration of the elastic cartilage and hair follicles in the ear pinna.
p38 MAPK Signaling in Pemphigus: Implications for Skin …
2013年7月10日 · It has become apparent that p38 MAPK is involved in skin autoimmune diseases such as pemphigus. Nevertheless, its targeting can lead to completely unpredictable outcomes and certain adverse side effects depending on the different cells participating in …
Loss of PLC δ1 leads to a decrease in intracellular Ca2+ concentrations and nuclear factor of activated T cells activity, along with hyperactivation of p38 mitogen-activated protein kinase (MAPK)...
Cutaneous wound healing through paradoxical MAPK activation …
2016年8月1日 · Here we show how the BRAF inhibitor vemurafenib accelerates skin wound healing by inducing the proliferation and migration of human keratinocytes through extracellular signal-regulated kinase...