Molecular and functional characteristics of heart-valve interstitial cells
2007年8月8日 · Understanding the complex biology of valve interstitial and endothelial cells is an important requirement in elucidating the mechanisms that regulate valve function in health and disease, as well as setting a benchmark for the function of cells that may be used to tissue engineer a heart valve.
Valve interstitial cells - Wikipedia
Valve interstitial cells (VIC), cardiac valve interstitial cells, or also known as valvular interstitial cells (VICs), are the most prevalent cells in the heart valve leaflets, which are a type of mesenchymal stem cells (MSCs) and are responsible for maintaining the extracellular matrix that provides the mechanical properties of the heart valve.
Cardiac valve cells and their microenvironment—insights from
During every heartbeat, cardiac valves open and close coordinately to control unidirectional flow of blood. In this dynamically challenging environment, resident valve cells actively maintain homeostasis, but the signalling between cells and their microenvironment is complex.
Cardiac valve cells and their microenvironment—insights from
2014年10月14日 · During every heartbeat, cardiac valves open and close coordinately to control the unidirectional flow of blood. In this dynamically challenging environment, resident valve cells actively...
Valve Interstitial Cells: The Key to Understanding the …
2017年9月14日 · Implantation of heart valve prostheses has been characterized as “replacing one disease with another.” Understanding the cellular and molecular processes behind valve calcification may possibly lead to nonsurgical treatment.
Heart Valve Development: Endothelial Cell Signaling and …
During heart valve formation, a subset of endothelial cells overlying the future valve site are specified to delaminate, differentiate, and migrate into the cardiac jelly, a process referred to as endothelial-mesenchymal transformation or transdifferentiation (EMT).
Generation and characterization of cardiac valve endothelial-like cells ...
2021年9月6日 · There are two major types of valvular cells: the valvular endothelial cells (VECs) lining the outer surface of the valve cusps and the valvular interstitial cells (VICs) embedded in a...
Evolving Concepts of Cardiac Valve Dynamics | Circulation
2008年10月28日 · The essential functional components of the heart valves comprise cells, including the valvular endothelial cells (VECs) at the blood-contacting surfaces and the deep VICs, and extracellular matrix (ECM), including collagen, elastin, and amorphous ECM (predominately glycosaminoglycans [GAGs]) .
Directed Differentiation of Human Induced Pluripotent Stem Cells …
2024年2月15日 · To generate heart valve cells from hiPSCs, we sequentially activated the Wnt, BMP4, VEGF (vascular endothelial growth factor), and NFATc1 signaling pathways using CHIR-99021, BMP4, VEGF-165, and forskolin, respectively.
On Valve Interstitial Cell Signaling: The Link Between Multiscale ...
Heart valves function in one of the most mechanically demanding environments in the body to ensure unidirectional blood flow. The resident valve interstitial cells respond to this mechanical environment and maintain the structure and integrity of the heart valve tissues to …