2024年5月5日 · Naloxone has been used as an antidote to opioids for over 50 years, and the drug has been readily available as a parenteral formula. Naloxone acts as a pure μ-opioid receptor competitive antagonist and is instrumental in preventing accidental overdose of opioids.

2024年5月22日 · Naloxone is an FDA approved medicine used to quickly reverse an opioid overdose. Naloxone is a opioid antagonist that works by attaching to opioid receptors and therefore reverses and blocks the effects of other opioids.

2022年1月11日 · What are some signs of an opioid overdose? What is naloxone? Naloxone is a medicine that rapidly reverses an opioid overdose. It is an opioid antagonist. This means that it attaches to opioid receptors and reverses and blocks the effects of other opioids.

Naloxone for opioid overdose; Pralidoxime for poisoning by anti-cholinesterase nerve agents.

Naloxone can also be used as an antidote in an overdose of clonidine, a medication that lowers blood pressure. [27] Clonidine overdoses are of special relevance for children, in whom even small doses can cause significant harm. [28]

2012年7月12日 · Naloxone, the antidote for opioid overdose, is a competitive mu opioid–receptor antagonist that reverses all signs of opioid intoxication.

2020年11月3日 · This opioid antagonist is a useful adjunct in the management of opioid intoxication, particularly if there is CNS or respiratory depression. Caution is advised in those who are opiate-dependant and naloxone should only be used if there is significant CNS (GCS <12) and respiratory depression (RR <8).

Naloxone is a medicine that is an antidote to opioid drugs. Opioids can slow or stop a person's breathing, leading to death. Naloxone helps a person who has opioids in his or her body wake up and keep breathing.

Naloxone is an antidote to opioid overdoses. You can now buy over-the-counter (OTC) naloxone nasal spray . It’s also available nationwide at the pharmacy without an individual prescription.

Antidotes may play an important role in the treatment of poisoning by greatly enhancing the elimination and counteracting the toxic actions of the poison (Jacobsen, 1995). Naloxone (N-allylnoroxymorphine, Narcan) has been used as an antidote to acute opioid poisoning since the 1960's (Clarke et al., 2005).