As shown in Table 6.2, the reaction gave a high ratio of 8E in strongly aprotic polar solvents such as DMF and DMSO (entry 1 and 2). 8E was also found as the major product in MeCN (entry 3), dichloromethane (entry 4), and xylenes (entry 5). To our delight, the desired 8Z was obtained as the major component in methanol (entry 6).

Paul R. Carlier, Cedric W.-S. Lo, Michael M.-C. Lo, Nan Chi Wan, Ian D. Williams. HMPA Promotes Retro-Aldol Reaction, Resulting in Syn-Selective Addition of Lithiated 1-Naphthylacetonitrile to Aromatic Aldehydes. Organic Letters 2000, 2 (16) , 2443-2445. https://doi.org/10.1021/ol006099w

迈克尔加成反应（Michael addition reaction）是指亲电的共轭体系（电子受体）与亲核的负碳离子（电子给体）进行的共轭加成反应。 该反应于1887 年由A.迈克尔首先发现，是有机合成中增长碳链的常用方法之一。

迈克尔加成（Michael reaction、Michael addition），最有价值的有机合成反应之一，是构筑碳-碳键的最常用方法之一。有时也称为1，4-加成、共轭加成。是亲核试剂对α,β-不饱和羰基化合物发生的β位碳原子发生的加成反应。

2021年4月3日 · 迈克尔加成（Michael reaction），最有价值的有机合成反应之一，是构筑碳-碳键的最常用方法之一。 有时也称为1，4-加成、 共轭加成 。 共振稳定的 碳负离子 对活化烯烃的 1,4-加成（共轭加成）。

2008年12月1日 · We report the effective Michael addition of a hydroxyl group to α,β-unsaturated carbonyl systems in a biphasic solvent system (HMPA/water). The mechanism proceeds through a 1,4-Michael addition of the hydroxyl group to yield the …

ADDITION RE-ACTION 1 ,4-Addition reactions of a, P—unsaturalß , carbonyl compounds and a, ß—unsaturat- nitriles with resonance-stabilized carbon nucleophiles, such as enolate ions and enamines, are known as Michael addition. The a, 13— unsaturated compounds undergoing Michael addition is called the Michael acceptor, the

In organic chemistry, the Michael reaction or Michael 1,4 addition is a reaction between a Michael donor (an enolate or other nucleophile) and a Michael acceptor (usually an α,β-unsaturated carbonyl) to produce a Michael adduct by creating a carbon-carbon bond …

2023年5月24日 · The Michael Reaction is the addition of an enolate to an alpha, beta unsaturated ketone or similar electrophilic alkene. Mechanism, examples, quizzes, and more.

Michael Additions. Enolates are weak nucleophiles and undergo 1,4 addition to α, β-unsaturated carbonyl compounds in a process called a Michael addition. The reaction is named after American chemist Arthur Michael (1853-1942). Two examples are shown below.