Guaiacol is a monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position. It has a role as an expectorant, a disinfectant, a plant metabolite and an EC 1.1.1.25 (shikimate dehydrogenase) inhibitor. It is functionally related to a catechol.

Guaiacol (/ ˈ ɡ w aɪ ə k ɒ l /) is an organic compound with the formula C 6 H 4 (OH)(OCH 3). It is a phenolic compound containing a methoxy functional group. Guaiacol appears as a viscous colorless oil, although aged or impure samples are often yellowish. It occurs widely in nature and is a common product of the pyrolysis of wood. [3]

2025年1月9日 · Here we investigate the O-demethylation of guaiacol in hot-pressurized water with HCl or H-BEA zeolite catalysts to elucidate the impact of zeolite microporosity on reaction mechanisms and rates.

2021年12月15日 · Guaiacol (2-methoxyphenol) is an ortho-methoxy substituted phenol (Fig. 1). Guaiacol has been identified as a biomass-derived antioxidant along with other ortho-methoxy-substituted phenols: ubiquinol-10, α -tocopherol, sesamolinol, and coniferyl alcohol [1].

2011年6月20日 · Guaiacol, or o -methoxyphenol, was first isolated from the tree resin guaiac by A. Sobrero in 1843. Today, it is manufactured by methylating catechol (o -dihydroxybenzene). It is used medically as an expectorant, antiseptic, and local anesthetic; it is also a precursor to flavorants and aromas, including those incorporated in synthetic sandalwood.

2017年8月17日 · Guaiacol is a small and mostly hydrophobic molecule that is able to interact with polar solvents via hydrogen-bonding and polar-aromatic interactions. Higher concentrations of...

Guaiacol contains total 17 bond (s); 9 non-H bond (s), 6 multiple bond (s), 1 rotatable bond (s), 6 aromatic bond (s), 1 six-membered ring (s), 1 aromatic hydroxyl (s), and 1 ether (s) (aromatic). Learn more about chemical structure at Mol-Instincts.

IUPAC Standard InChIKey: LHGVFZTZFXWLCP-UHFFFAOYSA-N Copy CAS Registry Number: 90-05-1 Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file The 3d structure may be viewed using Java or Javascript. Other names: Phenol, o-methoxy-; o-Guaiacol; o-Hydroxyanisole; o-Methoxyphenol; Anastil; Guaiacol; Guaiastil; Guaicolina; Guajol; Guasol; O-Methyl ...

It is a small biphenol molecule which can interact with the proteins of cell membrane through hydrogen bonding, pi orbital interaction and hydrophobic interaction. It is hydrophobic lipid soluble and can cross blood brain barrier efficiently. Therefore, it is a potent therapeutic agent with high bioavailability [50, 51].

Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is also present in wood smoke, as a product of pyrolysis of lignin. Guaiacol has been found in the urine of patients with neuroblastoma and pheochromocytoma. Type Small Molecule Groups Approved Structure