However, no literature is available investigating the mechanisms of action of the antimicrobial metabolites from Bacillus. In this review, we summarized 47 antimicrobial compounds based on their molecular targets in the cell wall, plasma membrane, intracellular processes, and other emerging targets. 2.

2024年9月1日 · This review focuses on the major antimicrobial secondary metabolites produced by Bacillus and Pseudomonas including their classifications, structures, mechanisms of action and genetic regulations. We have also discussed their applications in plant biocontrol and provided insights into future development of improved biocontrol strains using ...

2025年2月20日 · In this Review, Ahmad et al. examine how antibiotics influence bacterial metabolism and how metabolism, in turn, affects drug efficacy and the emergence and evolution of antimicrobial...

2021年9月16日 · In this Review, we highlight the growing body of evidence connecting bacterial secondary metabolites to the phenomena of antibiotic tolerance (that is, the ability to survive transient antibiotic...

This review tries to give a critical answer to this question by considering potential mechanisms of antimicrobial action of PSMs (inhibition of cell wall or protein synthesis, inducing leakage from the cells by tampering with the function of the membranes, interfering with intermediary metabolisms or DNA/RNA synthesis/function), as well as ...

2024年9月11日 · Gaining a deeper insight into the metabolome has proven to be immensely useful in discovering metabolic pathways underlying infections, identifying novel drug targets and biomarkers, and developing therapeutic interventions for combating antimicrobial resistance.

2024年12月19日 · In the current study, we aimed to identify a bacterial isolate from extremely hot environment of Ethiopia that produces secondary metabolites with antibacterial activity against pathogenic bacteria and fungi, as well as to characterize the antimicrobial potential of these secondary metabolites.

2024年8月31日 · Bioactive compounds in the secreted metabolites can be identified and utilized as sources of new antibiotics. In this study, antimicrobial activity of secondary metabolites from Lactobacillus fermentum, Saccharomyces cerevisiae, Pleurotus ostreatus, and their co-cultures were tested against foodborne pathogens isolated from RTE foods using agar ...

These benefits include the production of antimicrobial metabolites, restoration of the host microbiota, modulation of the immune system, and the release of digestive enzymes to improve nutrient uptake .

2022年1月12日 · This review tackles this issue, by reporting antimicrobial compounds produced from Bacillus strains, their proposed mechanisms of action, and any gaps in the mechanism studies of these compounds. Lastly, this paper explores omics approaches to clarify the mechanisms behind Bacillus probiotics.