Strategies to guide the antibody affinity maturation process
Affinity maturation is the process by which antibodies gain increased affinity, avidity, and anti-pathogen activity and is the result of somatic hypermutation (SHM) of immunoglobulin genes in B cells, coupled to selection for antigen binding .
Efficient evolution of human antibodies from general protein
2023年4月24日 — For our main experimental test case, we focused on affinity maturation of human antibodies in which our specific selection pressure is defined as stronger binding affinity to a particular...
Affinity maturation of antibody fragments: A review …
2023年8月30日 — Insights into the structural basis of antibody affinity maturation from next-generation sequencing
Pretrainable geometric graph neural network for antibody affinity ...
2024年9月6日 — Here the authors report a pretrainable geometric graph neural network, GearBind, and explore its potential in in silico antibody affinity maturation.
Affinity maturation: highlights in the application of in vitro ...
Affinity maturation is a key technique in protein engineering which is used to improve affinity and binding interactions in vitro, a process often required to fulfil the therapeutic potential of antibodies.
Insights into the Structural Basis of Antibody Affinity Maturation …
2018年2月1日 — Structural studies of antibody affinity maturation spanning nearly 30 years have identified a diversity of biophysical mechanisms underlying this prototypical example of molecular evolution.
Co-optimization of therapeutic antibody affinity and ... - Nature
2022年7月1日 — We mutate sites in the antibody complementarity-determining regions, sort the antibody libraries for high and low levels of affinity and non-specific binding, and deep sequence the enriched...
Progress toward improved understanding of antibody maturation
The first is the classical process of affinity maturation, in which the antibody adapts to fit more perfectly to the antigen structure. The second role is the generation of affinity-independent diversity and the ability to adapt to changes in the antigen.
Strategies to guide the antibody affinity maturation process
2015年4月1日 — Antibodies with protective activity are critical for vaccine efficacy. Affinity maturation increases antibody activity through multiple rounds of somatic hypermutation and selection in the germinal center.
Enhancing Affinity: Antibody Affinity Maturation 101
2024年4月11日 — Enter antibody affinity maturation, a fascinating process that fine-tunes antibodies, enhancing their affinity, specificity, and potency. In this blog, we’ll explore the science behind this critical mechanism and its applications in medicine and research.
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