How to Interpret Elevated Cardiac Troponin Levels | Circulation
2011年11月22日 · These levels used to be considered indicative of myocardial necrosis. However, with high-sensitivity troponin assays, circulating cTnT or cTnI can be found in the plasma as a result of transient ischemic or inflammatory myocardial injury.
Troponin - StatPearls - NCBI Bookshelf
2020年7月18日 · A basal amount of troponin is found in the circulation of healthy individuals from the regular turnover of cardiac myocytes. Troponin indicates pathophysiologic muscle damage when the measured value is greater than the 99th percentile of the normal range, about three standard deviations above the mean.
Cardiac Troponin Thresholds and Kinetics to Differentiate …
2021年6月25日 · Change in troponin on serial testing only marginally improves positive predictive value for type 1 myocardial infarction over presenting troponin alone (area under curve, 0.661 [0.642–0.680] versus 0.613 [0.594–0.633]).
A Brief Review of Troponin Testing for Clinicians
2017年8月7日 · A line of demarcation is drawn at a point that maximizes the sensitivity and specificity of the test, often by using a receiver operating characteristic (ROC) curve method to help determine the optimal cut-point. For troponin testing, this ROC curve method was initially used to determine the cut-point using creatine kinase-MB to define MI.
Troponin in Critical Illness • LITFL • CCC Cardiology
2020年11月3日 · area under the curve of troponin elevation correlates with infarct size; new assays are highly sensitive; Disadvantages. low specificity: multiple causes of raised troponin other than infarction e.g. PE and RV strain (see above) different reference ranges for different assays; elevated baseline troponin in renal failure
Troponins in myocardial infarction and injury - PMC
Troponins are proteins that regulate muscle contraction. 1 In the myocardium the subunits are cardiac troponin I (cTnI), cardiac troponin T (cTnT) and cardiac troponin C. All three are integral components of the contractile mechanism of cardiac muscle (see Fig. 1). They have separate genes, which differentiate them from skeletal muscle troponin.
Troponin: the biomarker of choice for the detection of cardiac injury
In this article, we review the biology of troponin, characteristics of assays that measure serum troponin levels and how to apply these measurements to patients who present with possible cardiovascular disease. We also discuss other clinical situations in …
Cardiac troponin is part of a protein complex that regulates contraction of cardiac muscle. Troponin T and I are unique to cardiac myocytes. Cardiac troponin testing consists of the measurement of cTnT or cTnl and used for confirming MI, or assessing prognosis. Elevated levels are associated with increased mortality in a wide range of patients.
Sensitive Troponin I Assay in Early Diagnosis of Acute Myocardial ...
2009年8月27日 · Cardiac troponin testing is central to the diagnosis of acute myocardial infarction. We evaluated a sensitive troponin I assay for the early diagnosis and risk stratification of myocardial...
The Predictive Role of Cardiac Troponin Elevation Ratio …
Non-ST-segment elevation myocardial infarction (NSTEMI) is a common form of coronary artery disease, and its prognosis is influenced by multiple factors. This study aimed to analyze the predictive role of the combined application of cardiac troponin and cardiac function indices in NSTEMI patients’ prognosis.