2013年12月6日 · Hepcidin excess resulting from genetic inactivation of a hepcidin inhibitor, the transmembrane protease serine 6 (TMPRSS6) leads to a form of iron deficiency refractory to …

This review emphasizes the most recent findings in iron biology, deregulation of the hepcidin-ferroportin axis in iron disorders and how research results have an impact on clinical disorders. …

Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic …

2013年1月1日 · Hepcidin manipulation to restrict iron is a successful strategy to improve erythropoiesis in thalassemia, as shown clearly in preclinical studies targeting TMPRSS6; …

2020年12月14日 · The major signalling pathways that sense changes in circulating or tissue iron levels to control hepcidin synthesis are the homeostatic iron regulator (HFE)/TF receptor 2 …

2011年4月28日 · The iron-regulatory hormone hepcidin, first described 10 years ago, and its receptor and iron channel ferroportin control the dietary absorption, storage, and tissue …

2006年2月1日 · Hepcidin regulates intestinal iron absorption, iron recycling by macrophages, and iron release from hepatic stores. In turn, hepcidin secretion is regulated by iron stores, …

2023年1月1日 · The regulation of hepcidin by iron is incompletely understood, but murine models suggest hepatocytes sense local and systemic iron status by binding bone morphogenetic …

Hepcidin binds to the only known iron export protein, ferroportin (FPN), inducing its internalization and degradation, thus limiting the amount of iron released into the blood. The major factors …

2004年12月17日 · Increased plasma iron, from macrophage recycling of aged red blood cells or from intestinal absorption of iron, stimulates hepatocytes by an as yet unknown mechanism to …