A biochemical diagnosis of Wilson's disease was established in 53 asymptomatic subjects, ranging in age from 15 months to 31 years. None had any pathognomonic physical sign of the disease.

Unbound/loosely bound tissue copper II ions are powerful catalysts of oxidative stress and inhibitors of antioxidants. Trientine is a highly selective copper II chelator. In preclinical and clinical ...

The most commonly reported drugs that trigger DM (in order of frequency) include hydroxyurea, immune checkpoint inhibitors, penicillamine, and tumor necrosis factor inhibitors. Immune checkpoint ...

Treatments for Wilson disease block copper absorption by the gut and increase fecal copper excretion (zinc) or increase urinary copper excretion (chelating agents D-penicillamine and trientine).

2,10,16 Other disease-modifying antirheumatic drugs (DMARDs) have been used in this setting, including cyclosporine A, leflunomide, azathioprine, hydroxychloroquine, D-penicillamine, and tacrolimus.

Wet Leg, Blossoms, Sam Fender and Myles Smith perform live. CREDITS: Roberto Ricciuti/Redferns/Getty (L), Lorne Thomson/Redferns/Getty (C-L), Matthew Baker/Getty (C-R), Prince Williams/WireImage ...

THE following case report describes the rare occurrence of the nephrotic syndrome after administration of gold salts. A 36-year-old Puerto Rican woman presented herself at the Arthritis Clinic ...

Trientine hydrochloride is under clinical development by Innolife and currently in Phase II for Systolic Heart Failure. According to GlobalData, Phase II drugs for Systolic Heart Failure have a 67% ...

Copper is an indispensable micronutrient for the development and replication of all eukaryotes, and its redox properties are both harmful and beneficial to cells. An imbalance in copper homeostasis is ...

Furthermore, patients suffering from diseases associated with olfactory dysfunction such as Parkinson's or Alzheimer's disease, multiple sclerosis and neuromyelitis optica spectrum disorder as well as ...