Here, Tsui et al. present a generalizable strategy utilizing CRISPR screens and lectin microarrays to identify and characterize regulators of glycosylation. N-glycosylation is vital for biological ...

Built around research by Stanford scientist Carolyn Bertozzi and MIT researcher Jessica Stark, Valora Therapeutics is ...

This useful study reports the crystal structure of SCARF1 and identifies putative binding sites for modified lipoproteins. Supported by a convincing set of experimental approaches, this study advances ...

Lectins are a kind of protein present in various foods such as grains, legumes, and nightshade vegetables. While they’re generally safe for consumption, some individuals may suffer from negative ...

IgA nephropathy is the most common primary glomerulonephritis and contributes to kidney failure. Growing evidence exists that the overactivation of the lectin pathway contributes to the pathogenesis ...

These two quality control sensors control lectin chaperone binding and glycoprotein egress from the ER. A quantitative glycoproteomics strategy was deployed to identify cellular substrates of the ...