activating and/or modulating the mechanisms of the ubiquitin pathway as research and therapeutic tools. A notable therapeutic success is the combination therapy employing the proteasome inhibitor ...

Such interplay is seen with ADP-ribosylation and ubiquitylation. For example, DELTEX E3 ligases were reported to ubiquitylate a hydroxyl group on free NAD + and ADP-ribose in vitro, generating a ...

A new review published in Genes & Diseases explores the pivotal role of the ubiquitin-proteasome system (UPS) in regulating the tumor microenvironment (TME) and driving cancer progression. The study ...

Amerigo Scientific announces its transglutaminase inhibitors, designed to advance research into their therapeutic applications across a range of dise ...

The tribe of Levi, which included the priests, did not inherit a separate territory in the promised land. They were to depend on the people’s tithes, as God had commanded. Forty-eight cities and ...

Necroptosis is the predominant form of neuronal death after ischemic stroke. This study identifies the deubiquitinating enzyme OTUB2 as a novel regulator of the RIPK1-RIPK3-MLKL necroptotic signaling ...