enzyme-substrate (ES) complexes - experimentally accessible as minima in the free-energy landscape - are composed of a vast ensemble of molecular configurations due to their macromolecular nature.

Department of Cell & Molecular Biology, Uppsala University, Biomedical Center, SE-751 24 Uppsala, Sweden ...

Department of Chemistry, University of Bergen, Allégaten 41, Bergen N-5007, Norway ...

Established methods of performing S N Ar chemistry often produce compounds as isomeric—two or more compounds ... is no known natural enzyme that could catalyze S N Ar reactions, the team ...

Structural and cellular assays and molecular dynamics simulations reveal the mechanism of action of γ-glutamyl carboxylase, which involves cholesterol and vitamin K. Protein kinase R-like ...

including the mechanism of catalysis of the endogenous substrate. COX is a heme-containing bifunctional protein that sequentially catalyzes two reactions, a COX and a peroxidase reaction.

Imaging live cells with fluorescent proteins has long been a crucial technique for understanding cellular behavior. While ...

During that time, he's become a huge fan of Doncic. The star NFL QB had two very honest and relatable tweets after the trade went down. He started with a stunned two-word message of: "Wait what?" ...

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There are two known modification pathways for lactylation. L-lactate can form lactoyl-CoA, which mediates lactylation under the catalysis of P300. In addition, methylglyoxal can form LGSH under the ...

That caught the attention of Ole Miss football head coach Lane Kiffin, who chimed in with a two-word summary: "Really sad " A notable reply to Kiffin's post from a fan said, "The grift of ...