2 (FBR2), a clinically validated traditional Chinese medicine formula, exhibits potential as an IPF treatment. Objective: This study aimed to investigate the regulatory effect of FBR2 on ferroptosis ...

Bioinformatics analysis revealed that SIRT3 was a key mRNA regulated by JT. JT activated SIRT3 in fibrotic kidneys to inhibit the acetylation of P53. Under the premise of SIRT3 knockout, JT did not ...

Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered ...

为探究非小细胞肺癌（NSCLC）顺铂耐药机制，研究人员开展关于 USP2 和铁死亡对 NSCLC 顺铂耐药影响的研究，发现 USP2 通过调控 p53 影响铁死亡进而调节顺铂耐药 ... USP2）和铁死亡（ferroptosis）在 NSCLC 顺铂耐药中的作用机制。研究成果具有重要意义，若能明确 ...

5Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, ...

为解决溃疡性结肠炎（UC）诊疗难题，山东大学研究人员开展与 UC 中 DRF 相关的研究。结果发现 118 个 DRF 基因，筛选出 XBP1 等三个生物标志物。该研究为 UC 诊疗提供新思路，强烈推荐科研读者阅读。

In recent years, there have been significant advances in our understanding of different forms of cell death, and how these are linked to immunity. This EMBO Reports article collection gathers recent ...

Simon Fraser University (SFU) Faculty of Science researchers have received $3 million in funding from the Canadian Institutes of Health Research (CIHR) through the Fall 2024 Project Grant competition.